ID A0A067CAL0_SAPPC Unreviewed; 1455 AA.
AC A0A067CAL0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN ORFNames=SPRG_10776 {ECO:0000313|EMBL:KDO23581.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO23581.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO23581.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO23581.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
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DR EMBL; KK583252; KDO23581.1; -; Genomic_DNA.
DR RefSeq; XP_012205729.1; XM_012350339.1.
DR STRING; 695850.A0A067CAL0; -.
DR EnsemblProtists; KDO23581; KDO23581; SPRG_10776.
DR GeneID; 24132866; -.
DR KEGG; spar:SPRG_10776; -.
DR VEuPathDB; FungiDB:SPRG_10776; -.
DR OMA; RFVRHYC; -.
DR OrthoDB; 50780at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR024983; CHAT_dom.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR049052; nSTAND1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR Pfam; PF12770; CHAT; 1.
DR Pfam; PF20703; nSTAND1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF13374; TPR_10; 2.
DR Pfam; PF13424; TPR_12; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 4..68
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1383..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1455 AA; 161250 MW; 10956CF9D474F3FC CRC64;
MEAWSCEKVA EWLEASGFGE FAQTFLENEI SGAILPDLTN EILRDDLQIK ALGRRAKILA
AIRDINDRDN VLDLAVLHAA PLVLRIYPKD APPTILAMEK LDLEAERLAL QQALNSGYLG
RIRLRFDVAT TDSFRALLTA WQCKVLHFSG HGVGHNEMLC FEDGAGCTHM ISPKSLRELI
YSGAVGATDL LQVVFVSSCH SERLANVFVE AGVPHVVAVH SDSRILDSSG NMFAKHFYLS
LFAGRSVLAA FDIAKTAVRA LPPTNKRACC CAHLHERTCQ WALSGMVHAR HPPNRCCCKG
ETLPWPHDES SKFLLLGQAD ASLHDVVIFP KLPRGKLVDL TPHCPSNLPA MHGQFVGRNV
DTYNLVRSIV QGNVTVCTGA PGIGKSSLVI AAAHFVLQRR ICPDGVFYVD LEGLAGLEFS
AVLYAIAQSV GLPVGENTTD SQLFAELGSK RCLLVLDKVE ELLDRDQRKC EAFLGQLVAT
AHHTRLLLGS RRIPDIANVT VTSVNISELP LKIATELILS MALQCSPVEA ERLATICGKL
PLALRVVGRA LANTRSNVTP QDLIERLQVE DHRLEEINNL SETGQKECLD RCIRSSFTQL
DAPLRLAFMA LGLFRGVFDM KAACAVLQSF TSPSPLMKTH SSPSILSSST PSMFAPPSYS
RQYGSSNALD ECASTAASSA QSLGWELYHI DDCFDKDDAL TTMSYSLLNL ESQEEVTAHA
SEVAAAIPAL EQLNQWSLVE KVMPMILRKT TRHVLPQHAR FRLHNMIQLF AEDEAAKFSV
SSPEGAALFL AWRRRFVRHY CLVIANASHA FRYEGSLTLF DSERSNIESA LRIAHQLSKH
SEETARERMA TGCEDDDGGY APFIDVLLHS NLMVRGRFIF RARMDPRFRL RLFATSIQFS
KTARVLNCKC GHIENNSTIL DTSDMPSSYE PSQAPEAAPP CACPGVMELL ALEVLMVMEM
GYAHYDVNED ANAEHMYRES LRIQQEVLHR TDHSHVAEAL NYLGIVLSMR RGFSPVNAWK
FRKAEALLLQ AKEIRERVLG PVHPDYATSL NNLGNFYKSA LTMLKDEGDS SSMGLGYGGV
LLKTNDEIQE LYEKSLSIYE AHLGKDHPLV ARSLNNMALF LVHITDKRKP SPQKMSEIDA
KIEQLYLQAL DIRRKKLGNK NPETAATLNN LGNHKYNQGQ YAAAETYLRE ALTIRQQYYS
NTNDRVSVTL LNLARILVAQ EKYKEAEMMY REAEAIRQVL MPNSRELGFC IEKIGRCMLR
QGLEDEGKKL ISKGQHMKRQ SGFQSRRPST DSFGSFDTAS VASESFNDSF KEQLYIHDVL
SDEALSSPDF NVEGQIIGKQ GANLRRIEKE SGAQFVGTCE DAVAAAKTLT IEHLKDIQFR
FEKKLAQPPG ASTQATGRRP PRHDERRGKA GRAGHKSHHG GRGSNNNSNS SHAGGRGAGR
SSTMHVSLED LLHKK
//
