ID   A0A067CBF4_SAPPC        Unreviewed;       691 AA.
AC   A0A067CBF4;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN   ORFNames=SPRG_07917 {ECO:0000313|EMBL:KDO26515.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO26515.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO26515.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO26515.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
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DR   EMBL; KK583223; KDO26515.1; -; Genomic_DNA.
DR   RefSeq; XP_012202659.1; XM_012347269.1.
DR   AlphaFoldDB; A0A067CBF4; -.
DR   EnsemblProtists; KDO26515; KDO26515; SPRG_07917.
DR   GeneID; 24130167; -.
DR   KEGG; spar:SPRG_07917; -.
DR   VEuPathDB; FungiDB:SPRG_07917; -.
DR   OMA; HEASAAC; -.
DR   OrthoDB; 51760at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR46270; ARMADILLO-TYPE FOLD-RELATED; 1.
DR   PANTHER; PTHR46270:SF2; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT   DOMAIN          110..244
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
FT   REGION          269..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  74322 MW;  924F1D2E61A4E422 CRC64;
     MGAGASTQDL RLLSASAIAA EVVGLGSAYA PYEAGILANG VDGDVVAHLQ SEQLPMLFGT
     LGVTNTIHQT KLASLHSQHR KALLTRSLSM ANHMTAKLSA SPRKPKTFDV FLSHNWGHDE
     LGRDNHARVA NINAFLRQNE IKTWFDQDKM HGNILKAMAH GIEESQIVLV FVTQLYQTKV
     NGDNANDNCQ LEFGMAKTTQ TAQWMIPVIM DPCMKTPRHW CGQFKLVLGN QLYVDLTSDE
     DDAFIAGCTT LLQRIDALLL KLGRPSVLPP THRSSQETQA PSSPRTTDSA SELVTLFTTW
     QRGIEAHDVD AEQDTVAAIV DQLSSPEVAL PSGGFPWSCL AHGFTSLSLG LQDDACAMSV
     LLLDRLPTTA ESLLSFPAVL PFLLEAVTRP QGDAPPNAIV LLCNLSSVET AAPALLASPV
     IEHLLTGTAT EADDYWLPRL ETVANLAGYD AAKDALVPYY AHLVTIMTGV PSVAWCILRI
     CLHVAAHEAS AACLLEANVL EAMLALLPRP DEMVLKVVRH LVQQPLAALR VGSSALWGSY
     LLQQTKEGTF EHLCHHTIAG LSVESKSMQA LLPHAHAWLP LWAAAIAKGS LTVSTIACNL
     SLLPEWVPLL SAHAELLDAL GQSVHAASDL GAAKSLANLC TWAQESQADA PALQAALRDR
     AETWAALAAS TSDSEMQVIA IQIQHTRQVD A
//