ID A0A067CCF5_SAPPC Unreviewed; 5416 AA.
AC A0A067CCF5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=TRAF-type domain-containing protein {ECO:0000259|PROSITE:PS50145};
DE Flags: Fragment;
GN ORFNames=SPRG_22259 {ECO:0000313|EMBL:KDO24507.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO24507.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO24507.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO24507.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
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DR EMBL; KK583241; KDO24507.1; -; Genomic_DNA.
DR RefSeq; XP_012204824.1; XM_012349434.1.
DR EnsemblProtists; KDO24507; KDO24507; SPRG_22259.
DR GeneID; 24142642; -.
DR KEGG; spar:SPRG_22259; -.
DR VEuPathDB; FungiDB:SPRG_22259; -.
DR OMA; NIDCTAT; -.
DR OrthoDB; 55292at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR46730:SF1; PLAT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00207}; Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00207};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT TRANSMEM 4275..4298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4375..4393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4405..4427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4823..4844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4850..4871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4878..4895
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5107..5180
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT ZN_FING 5107..5180
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT REGION 3806..3836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5249..5270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5387..5416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3806..3829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5402..5416
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KDO24507.1"
SQ SEQUENCE 5416 AA; 576027 MW; B8EE16C145C0AD58 CRC64;
PYVVGSVLFS VQALVTQSTL QPLVVTLHSS IASGYAALFD VSCSLPVGSE TFSITLSLPS
AYCDAVSMVY MFDRLVNAAE DGCSYVLQDG TGRTSWATWF SGTVFLRVAP GFSGNMTLQY
TATSGNVVGS TAQTIASVSL VWDADTDPVV LPGTFQWLEA YQNELIFRDW KADVEDVLNS
AGETLHGNAS VHFECDHLNR GITGGWASGA WMPCDIEALQ DVYDVALAPA LDFSGRTAVT
LVVTEARYLA RPIQCVIQYT IRIIEVAPLP ALTLPVTFQP HSVIAYGQPA MIALAEPVAS
SSSLDLDILV DATTLLYEAT QPPRSQARAI ATDTFVFQPD ISPIVYTTVK SPLLAVACLQ
GEPATLNLTY LGASNTTLWV MVVPRDVPLQ INRASAATLD PVKLPPTQLL HVQPPAYFTG
RLQFDIRIGL QRGQRTAIVP YAAVVDVTPL PVPPVPRVVF CNRSVPFGDV AVVTMTNVPL
STTTAFAIEI EVLNATMASS LIAAQVVALE TISHFPAQYH YANVTSATAW KWTLPVVLLP
SGTVADRHLV SLSVAVHMAP DFAGHVPLAL RLVSFLAANA SVTAEWVYHQ TVQWHYNQVP
LVEVAPLWTL TTLENLDTRV AWMALLTQSS LIGTYWTQAY NLTGVSLQYG VNKTVRDASI
DTFFNATQSA TVVRASKLLA WSLNDSMSEI TSDDAMQLYV LPYRYGSTNV TLNFTFHGAD
ESIRPRILMQ PIQLDVLQVA QVPVIDSVRS PAVVASDDIA DVTVQIATPI LDGSDMLTAL
LWTDSPSVAV QNAANVVLVP HQNETLPRYG IPFGTSFYQS IQTWSATFRV MALGSFSGKA
NFCLEIRAIA TTNTTSRASV FHRFAIDFEP SDTPIVVPAS VVSMAVFGGE IWTLDAPAIL
RQTNAQLPLP YATAAIASAS YEYTLETANI HYGFASVVPR VLAPVRVALN VAGVPPLTHD
LVHMEAANTS TYDQPITITL TLQCAKAVVH FEPTTLAYLV NGRSVQDTSV LNMGQPIQVV
AWPPLGSNFS GVIPFQVSAL CDHGPALSVR KDLQWLANPA SFLLPPTTAN ASTNENTWLQ
MALGSMLSAT NRTVNDIRYR VAALRYVTPL DDNIQQVELG NATLLDSNYI GLLPRVHFSG
VLSVTWLVEY EGVGTQFGQV VALQNQTATH TMLVAVHPVA VAPTLDLATD GVVDFGNYSR
ATLHVTIGGD TSQTTQLYLA CTGSIVAFSG GRWLPYFGSV QIGTLNLNTT LQWIYAPSQA
AAGTADCTLH SMTTSVDLGL GTDPRQMLAT QSVNWTATWQ PSVHVPVMPV QTLSFTTMVN
RTLVLSLPDL ISSLPNATSC ALQWYTSDVQ RTLADGVVVN ATRTSQLTPA FAQASGMSCA
NLSQLTVEFA SSYVGRTTLF LGVETLVAQY PVAIAVTVKS LPVAPHVLLS TNAVVASYEQ
PVSVVAYAPA PPGTLVTYHV VSSPPIITAI GRSGEWFTAD VYGIISMRPW AAVDATLQVA
APIGYVGSVL LTITALVQNG ADGASDAQQL NATWLRALPP SLQVSSVDSM YATDVASIQL
QTELQHQDSA IGALSVLMTT SHALQDVTRT LQASPAAYHV QLPTNELLVT PLRYFGGPIV
WTFQATSTAF GTSAISVASL NMTVVPVVST PNITLGVPAM VQNTSSRMSI QVALVEPLGY
TEVSKSTLVF SSFGIDAITD ASTNASVPCV VVGPNVTACP LATTFGAARN FSLVLTPYLD
YAGPVNFSVL TIHSILEAPL GCMESAWNSS MLHACCENVT SQCTASSSAA TIVVRGIAAY
PNVSVSPISL VSSVQAISAV KVLALDVHDP FHSQLLTATI VCPLNTLHRV VVSQNYTRTN
MTKLTSVNAS SMDMFSVAWL PRIAPWGLEL EWSANATTPR FNCTLVAQSR SVLFPNSTAT
TNTTFFVELN LTPPALTLSQ AYIEVQEGQP IVLAAALATA NATLVLEAPL AVIQRVAFQN
ASMLYATTTQ IGNRTFVYGG ASGIRGSFVL TTFPTSGDVT LRLYSFPTIA SAMTILNATS
AARVLVHINP IPMLPLFLAS PSVLFVPTSM NNVTTNVVVS MAHVDVDNVV YLQVGVPRFL
VTDLSWNGQL QVPQSINTTS TLTSGTMTLA VQSYYDGHFA VTLDAFSVVP ALGLTASNRS
FLSVVAFAST LDLTNLVVAS SVEGGATDFI EIPVTSNVSD LVLLDLEQHH LGTVVANGIV
LTRTDWGNSS IPSYALPQPL MQLHVRSRPG FAGFFTVALA GVDTSLALGI APVRVHVQPV
ALPPQLLKVS PTIINGTTVY LDVVSDVPSP SNGVDVLTLT MTLPVYVPVI ACSVPSRASI
PVRVNGTFRT FDVPSTTTTV RFVLAPNYVG TFSVAVLLTD TSGLVSTASV ETMINLVIAP
RTAPPAVGWT YALSSQVPSI SVVENALNTP SLLNATSLLN GSSAWNASGN VDVSSAFSIA
TLPSTATHPL QSSITFNGSE TWLAFVPTVS VTDLSDLEIS SDVPRLLSSR IVPSKYFDGY
VVLAPHLVWT TPYTYGAMTT LLGATTASLH QATGVSLQTT SQSSRVVAVA VRITPVAQVP
TVTLQLPPPI AGFGPWAVYE ADAVNFTINA TTVYAVPTQV LHTRLSASST QLTSISINGT
VLALPKVGPV VFPSTLPANV LPVTTVSLPV VRGVFGLLPM QLMVQNTETL NNDSQLVVKT
WNVTVVPVAH VPTLVLQPSA TTLRESDVLQ LTATATVLST TENISISVAS WPTEAAVTLQ
HRDATLSHLP SGALVTLSLA KYWSGTLQLN VTALAQQSMA SPRDKASTSQ LLNITVLPVA
YPPLLVVDPS KHGVMGTWVT VPINVSALVV RRSSDIDEWS LHLVARAGAL SVWANQTLLT
RNASLSNITL DIFSLPVSGE HEPRRHHKDK RDNGAAIDLF IAGIHVSANA TAMDQGTSVL
FTVAVNSPPI APVTITLACN DTSRLIVPAP LVATTNTTLQ WLLRSTRDFM DNGNNVVNCA
MVINTTDVYY QQVPLPNTSL VLVNKDTSGF ALRGTMLNNR VQLTVAEGGF PDSYTVALTS
KPFDEVDIFM TSNVSYLRTT PPLLVFTQDN WNVPQTVVAN ASKESNIIGM APAFILHTIV
TNDTKYAALQ NFTVGVSLLV TSDTTPPPAL QSAQFGNTGA DILLTFSRDV DLSSFPTPTS
FVCTRLLVFT TGFYGDVPTC GWTSKSTVRI LLGQSPTVLP GDKCQVVAGL KATATSTLSM
PTSYIVIQTP VNPPVPKVSV TGPQNLGSCD DLVLDGRSSS GGGGRAMAWV WTVTNAPDIA
ATLSALGTTA QTVSLPASTL IAGGTYTFSL TITNFFGAFG TSGSIVVTKA STPLPVVSID
GPSAVSLTKA STLALNSVAT PATCGNTDVS SIALSFQWSM LGSSGVMTVV NSTSRNPRQL
RLPLRTIAYG TYTVQVLVGV VGHPAQINSA SVTLQVVPSA LVAVISNGFR SVGNQADLVL
SGTASNDPDS SSTTLLYAWQ CFDAMTGAVS CGNVSINNGS TSTVAKTNLP PTTTIRILLT
VYDPVTQRSA QASTTYTVLL GSPPKTTVAP LSQLKYNPDV KIVLNGAVTS AIDSSPTTLW
SVQGDATVAD TAFGFARTSK RMLLLPNTLT AGKTYVFVFT GTDKFGQSSN ATISVQINEP
PTSGLLVSSP TSGTTLATPF AVSCLNWVDV DLPLTYAFKY IVGPASADAT EIALGDYALS
TAFTTIFPLG GGVNSTITIV AYVADAYGYA TKVYTEIVVA APTGSASAQQ AALSDQSSQL
VASAASTDPG QVVNLVGMLA STLNAPPATT TSSGSSSGGS TTTPAPTASV APGRTPKPTA
VVLKSCPSLS AALVCSGHGA CVLNPPKCPA TNIDCTATCT CEPSWYDSDC ATPQGYYDQK
QAMLGNLLTA MASATSSIEP TAKAVEQQTS AVQSITANSG LLSPTQQTQA LDLVAGVLSA
SSQVQLSTAA TTAVGRSISN LLDAPSTTKS GPRRLSETTN STADAAAKAI KIQSTVGLLA
SAMLNGIVPG EDPVEMNSKN VKMVLQRHDP ANLQGTLELP LSESQVQANY SKQTFTLPTT
LPASSACAQG VDTHATFLAQ NVYQYANASS NINSGIIGLK LLCDDSSTPL AVANLTSGIS
IRMRKLAQYP VPGAPTSGNV SCTAGPPVHF NITCDIDQQL YKLVACNGSA NYTVQYTCPQ
YIPTPKCQYW DTTAGAWSTA GCRQEPDPDD NYMLCVCDHL TDFSTQVDMA FQAVEDNFFS
VIEHQTTVED VVQNIGIVIT MGVMVILYGV SLLFCLKWDR DDRAKRRKYA LTKQNEPTHI
DLRSLFVLPK VAAAKTRRAK AQALLSGFWD GLKAKHRILS TILRYDETFT RPQRAMVIFT
VTMSQMLINA LLYKLRQMDT SVATVIVSGL VSSVCLMPVT LAFVILFRKA GKMHDYTVRY
EIEDDDRIVE VEVDAYGKPV QYSQYDMLCI DLQGLLNAVP HGAYARMLAR LERDGNLTSL
ASIVSQSLYL ILHNREVREP DPLDDIAVEL VSKNLSTAAQ PRFSLFAKPK VLSMAIETHV
DAPVGADPGL LSVESAVAKL LALWSPTTDV YGRLNKFEPT AITSSTRSKL GYLLQEAIEL
QKKETSTAEV DELASVASIL AWCRKCYECA ECFANDTNAV LRHAKHEMQR TREQLVMTRR
MVQKQLRDRL QKFRTNVVRR SVDHQVQVVI QKSKHHMTET RRRLQDARRK SRVARKLQTK
EVKKQMAAVL GSLHGLTRWK KRFELYEEAK EKRLADAMPL HERQRYLNES EKLKKLRFGA
RLMYNLFLRK APQRLEKPIF PEFVNYILYA VCAGIDAFAA YFVLQFSFTV GHAVASMWIG
SLFTGLAMTY LVSEPVHIFL RVGVLPLLAS IFLVNTGLFE ALGTEIVTVG AAAAVGIAGV
AKFREKKAAR LLPVSVADGP SAQLASADAP PVLASAPSTR LVQTSVSAPL PSEPAPVVPE
PVAPVAAGPP TTSLESPVAP RRKSLVEGDT TEPIASFPTL TKVIVVSPRP APSRGASTAM
LVTGPSVAAL PVMAQETTSD ATSSVRAADP VDVAAALTTE LATPPPAVDE FVCECGASTP
QDARAHHLEH DCTHRLVQCR AGCGIYIQLR ARSSHEMSQC RLLLCACGKM VLRTKMASHL
ESECVQRSVT CRLGCGASMP LHAREKHERS VCDLRVTSCP DCNTVLPVRE LATHRAACTT
KAIVRGPATK LLVRRQSSLL ILGDDVLAEP SNERPVSPPS PTTTSLQGPP LVIPTVKAPR
GPLAAPTTTN VARRARAPPA AAAAPGEMQG PPLVLAPGAM ADEAKAKNEL ARKGVAMAAA
ADGAKRLTNE SDAKPRRADV SEAVVETTGA GQMAKSAFEG AAATLFDGTA PVRTQPLRGP
RAANPFQPPP DAKPST
//
