ID A0A067CGL0_SAPPC Unreviewed; 1014 AA.
AC A0A067CGL0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=SPRG_05586 {ECO:0000313|EMBL:KDO29633.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO29633.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO29633.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO29633.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KK583205; KDO29633.1; -; Genomic_DNA.
DR RefSeq; XP_012199693.1; XM_012344303.1.
DR AlphaFoldDB; A0A067CGL0; -.
DR STRING; 695850.A0A067CGL0; -.
DR EnsemblProtists; KDO29633; KDO29633; SPRG_05586.
DR GeneID; 24127976; -.
DR KEGG; spar:SPRG_05586; -.
DR VEuPathDB; FungiDB:SPRG_05586; -.
DR OMA; FSFMPEF; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 46..312
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 559..971
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1014 AA; 109395 MW; DC4253751720AF89 CRC64;
MFSLDAPLQP AIDGFVDPEN GEQQHTTHLN NVVMSVHRKT PIEQVIQGLG AHLTHVQDKR
RARATLLLAE VLTRLPDLRL SSDTAHLLLT FFLERLKDGP SMAACLKALV ALISLHAALL
PANDAWTVVE TLLNLPTPIA SLSQSMRKQS FELLQLIVRR GALGDHEGRV LMDGFLRAMS
GEKDPRNLLF CLRFAAELLT TYANVVDADV AKGFFDATSC YFPITFRPPP NDPYGITSED
LVLALRSVFV GHDSLAKHVL PMVLDKLSRT TVVEMTKDIL ETLAFCCAKY PLNRLLLHFT
PVAAAVYHHV LHGDNTAVIA VAIDALKTIT RAVSPPSKLP GMQALAWNKC IVYLVNQAVE
DLAHQAPDSM VSTGAGHVLC AIASVGVAGF SHVLSSALAL LLEQCAAQAG SPAEAATARL
VQLLGCIDAE VDHSAPPLVP YVSAIQTTLV HGLETATSSR QQKLCLQGLR CLVLRPPSPL
LDDASLEVLL QGWTSTVLSN PFPDVRDEAT STLQAIALKS PGLAQIVLTR CVPSFLQVLE
QPAANAASGR SIEVMVHDTL AVLTQLSLAP AIFEALLLPL CQISWTHPFA TATMAAAADI
VRVNKGSVAC MDYVILGTRD TSSSVLSRLV DALVVHVRTQ SIDVRPIVRA TASMSAHVMQ
CGSLPAQTTL LTSTLQLALT SDISPLRGHA QLLPLLNAVL YSCGAALTAL EPDVLPRLLP
QLFTLAAQSR GDDESIPKAL AALFNVLPED TPLFAAYLKW ITSPDARLEG MASPAAVILD
ATCSQDTRLA ALQTYVYLCK AMVLRGHATY APAMLSLLCS LLTSPFDLRP AVATSFAALV
AESDDVLAPA CHASISCVHR QRTFAHVFPL LFQSNLDYEG RVALLLIVAH TPQAILVPSL
AQIAPLVILA LTETGLLGHS ALATFKMCLQ QDPNLVQGFF KDVFNGLLWQ TQFGQSARDR
MDALECIGVL ASTKYDLIHP YKEMVIKRLL APIDDRKRVV RQLAVKVRNQ WSIL
//
