ID A0A067CI88_SAPPC Unreviewed; 701 AA.
AC A0A067CI88;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Na+/H+ antiporter NhaC-like C-terminal domain-containing protein {ECO:0000259|Pfam:PF03553};
GN ORFNames=SPRG_04989 {ECO:0000313|EMBL:KDO30193.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO30193.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO30193.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO30193.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KK583202; KDO30193.1; -; Genomic_DNA.
DR RefSeq; XP_012198893.1; XM_012343503.1.
DR AlphaFoldDB; A0A067CI88; -.
DR STRING; 695850.A0A067CI88; -.
DR EnsemblProtists; KDO30193; KDO30193; SPRG_04989.
DR GeneID; 24127403; -.
DR KEGG; spar:SPRG_04989; -.
DR VEuPathDB; FungiDB:SPRG_04989; -.
DR OMA; NTWNMSI; -.
DR OrthoDB; 36370at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..701
FT /note="Na+/H+ antiporter NhaC-like C-terminal domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001637786"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 258..600
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT REGION 341..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 74398 MW; 8476DE26E8B875E2 CRC64;
MLRLLLLGAA AAMGLELQVP SVLLTSVPFT ATMTLPAGSY PTLLDYTIQD QAGAYLASGV
WNVSQPLTTT LSLDASGANV LRCHAWSNAT SLRATRDVRS FPGYVSLLPP LITLLCSLLM
GQVMIALLVG IWSGAALVSG GNLWLGFLHT FDVYWVNAFV DRSHAGVLLF TIILGGTIGV
VQKGGGAHGL AHLAASTMRT SFRMQISTWV LCCCLFFDDY SMILILGSSL RQILPRTGVS
KEKFAAIIHT MGVCLPSMAP VSSWIGVEIG YVAAVLTSLN LDWDPFVTCL SSLQYRLFPV
LFIAFIFIII IFEKDFGPML KYERATAEAA DDVGVDELET DQIESNELDD NDEKPLGPME
PNPRKPMRAL NAVVPFTIIV AATFVGMILD GFQSLAAEFP GESFGVLDAL SHSDSVAALI
RASALGWVVA VVLLLVQRIL SMQEVMGAWI EGVKDVMEPT LILTLAWALG AVIGEVQTAG
YIASTLHGQI APGYLPAIAS VLCCVVSFAT GTSFGTMAIM LPIICPLSFK VSGQDAANLM
QCIGAVLGSS VFGNACSPIA DTSIITALSV NMPLQNHVES ILPYALVVAG TSSVGTLLLG
AHVVTTFTAF ALCFVTLLGL VAFCGSRVPS RFRSSSNASS VLSLSPSHRY SFLSTVSPPA
SREQDRLLPP PAPASSSSSV LDYVHKLFPS TKPSEKKTTP A
//
