ID   A0A067CP36_SAPPC        Unreviewed;       982 AA.
AC   A0A067CP36;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Peptidase M16 N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SPRG_02716 {ECO:0000313|EMBL:KDO32238.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO32238.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO32238.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO32238.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; KK583195; KDO32238.1; -; Genomic_DNA.
DR   RefSeq; XP_012196696.1; XM_012341306.1.
DR   AlphaFoldDB; A0A067CP36; -.
DR   STRING; 695850.A0A067CP36; -.
DR   EnsemblProtists; KDO32238; KDO32238; SPRG_02716.
DR   GeneID; 24125258; -.
DR   KEGG; spar:SPRG_02716; -.
DR   VEuPathDB; FungiDB:SPRG_02716; -.
DR   OMA; NDEERTW; -.
DR   OrthoDB; 129328at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          45..176
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          207..337
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          398..671
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          704..861
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   982 AA;  108694 MW;  1479C98D9DCACA03 CRC64;
     MTSVVDASKS PSDLSAYELF LLPNALEVLL VHAPPTLSAP RSGEDEVSEM AAVCLTVGVG
     TFADPPPLLG LAHYLEHMLF LGSAKYPQEN AFEAYLSRYG GYSNAATDCE MTKFFFEVAP
     HGLLKALDIF ANFFIAPLLL LESMDRELVA IDDEFQSANQ HDRVRLQQVL CDAGRRDGST
     HPYHQFGWGN SASLKDASNE PINVRVALND FFKQHYTAGR MKLAVCSSLP LATMAECVRN
     SFGAIPSSTA PGLWYPPLPR LAPPGRLLTF ESISETHALH LFFALPPTTN GRDRQSQLAA
     AEYLRYVLRH EGSKSLLHYL HQKGWATAIE AGIAETQGYE HGSYGSIFEV QIDLSLLGVA
     HWDIIVTHVY SILHYCQHTS NCPSWIHAEF QATAKVAFAF PAPVDPISRV QALATYMLDR
     LDVDRKELLG LHLGPCLYQP FNPAAIATLL TFMVPTNMQV ALVTTVHSSD IRRLHDRSPC
     TEPWGRIAYE TARIQPKLLA RWTMATPAPY RLPRANPFMP TDFTIEAETS DATPLRLDVP
     GRHWLQRSTL SPRVTAFFQL VMPFGQASVD THARLLVYVR LAELRLRETK YFAQCAEMDV
     NIRVQDGSIH VSVAGYRHHL PYLVTTLFDA LTRPEVPRTV ELDPVVELLC AELASDVADV
     GAMATYIRLQ LLDASPVQHA LDDVLRALRS LTITDVSAFI SSPQLFARAH LTSFVAGNAS
     KSTVVTLAHQ LVGMLSMPET LSPRSHALYS PKRLQTSTLP VHDGRGLLVR VLSARTDDVN
     SCVEMYFQCG ALHPKELAIL NVLRQLMKEP LFHHLRTLES IGYHVACYVK VTHNVLGYAI
     VVESATSNAS AIARRLDAFL QTTFPTILRA LSPDALALRL DAIRAIWQRP SVPHEVWAAL
     LTGQNGIDDA AMQAAVRAVT HQDLLAKYDD WFLTSARKLR VHVVGQDHAV PNVPLETLVD
     ASAAPILIQD ISRFKQRQPA TP
//