ID   A0A067CQK8_SAPPC        Unreviewed;      1504 AA.
AC   A0A067CQK8;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN   ORFNames=SPRG_02471 {ECO:0000313|EMBL:KDO32773.1};
OS   Saprolegnia parasitica (strain CBS 223.65).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO32773.1, ECO:0000313|Proteomes:UP000030745};
RN   [1] {ECO:0000313|EMBL:KDO32773.1, ECO:0000313|Proteomes:UP000030745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO32773.1,
RC   ECO:0000313|Proteomes:UP000030745};
RX   PubMed=23785293;
RA   Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA   van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA   Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA   Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA   Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA   Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA   Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA   Russ C., Tyler B.M., van West P.;
RT   "Distinctive expansion of potential virulence genes in the genome of the
RT   oomycete fish pathogen Saprolegnia parasitica.";
RL   PLoS Genet. 9:E1003272-E1003272(2013).
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DR   EMBL; KK583194; KDO32773.1; -; Genomic_DNA.
DR   RefSeq; XP_012196437.1; XM_012341047.1.
DR   STRING; 695850.A0A067CQK8; -.
DR   EnsemblProtists; KDO32773; KDO32773; SPRG_02471.
DR   GeneID; 24125026; -.
DR   KEGG; spar:SPRG_02471; -.
DR   VEuPathDB; FungiDB:SPRG_02471; -.
DR   OMA; PFYHENN; -.
DR   OrthoDB; 3076794at2759; -.
DR   Proteomes; UP000030745; Unassembled WGS sequence.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47455; ADENYLYL CYCLASE BETA; 1.
DR   PANTHER; PTHR47455:SF1; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT   DOMAIN          463..497
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          69..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          754..794
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1447..1478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        766..789
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1504 AA;  163555 MW;  5E5AAF96C97AB807 CRC64;
     MEARATRITR EEKKELDVLS RYVPRIVLSN YIASRAKLEA PAIASFTAVV ALFDISGFST
     LADRLAREET HRAPVPTGAE AKSRMSMTGK LDISRSASHR RVSTASDKVS LRIGHDVDDT
     APSSDKRGSI VGDKASFPER HNSTGDASAK KSMPARAGMA VEQLTRHLNQ TLAPVIDIIT
     EHNGDIIKFA GDAMIVMWET ESSAPRTDST PLTPVDHGLL VHTAILCALK VLGMLRGQPA
     GSHRLGMHVG MGLSTVTGNH VGGLLNRWEF YVAGHANQQM SMAEHDAGEG ELVVSSECYH
     ALVASAAIEN LAVQSTVLLT GNYRIDSLES NTPRVYPTRP LELSGDLIPL IKSYVPGCIS
     LSLGKGKLVI NGMRSITAIF IKFSEILTIT DPQAQLLEVH RCLCAVQDAA YRVHATIRQF
     LIDDKGAVAI VIVGLPPFYH ENNALHGIRM ALYLQEKGVK ACIGITSGPA FCGSIGSAVR
     AEYAVVGDTI NLSARLMSVA LPGQILCDEA TQSATTTLFE FDQGSPVLVK GKGTTITVFR
     VFRDANTDNK AHPLDHGEIF LSPDIYVNVI KRVQAFAARF QSTDSSHMPS EQLDPLQKRV
     VLLRGLTGVG KSCLLRHLTK VHPNVVYAAG DSVEKNTPLY IWKKLMSTII CGTNRVKAHR
     VEESDAGFVV LGRRLSVLDH NNNASRSPNG SGQTLATAGS MRSLPPTVSG SARALTQNTL
     ARGVSWRTNT LAPSPSGRMI DVIVVNTEKS RLPGAVVTSK NSGNNDDDDN DDDDDDGDDD
     DDDDDDDANA DRSRVESLVS AVRIDQSIAL GSGLAFVNSV VQSGSLSPEL LPLLNFFIPH
     CFPENNYTLA LAANKDALLK ELIVMVVAIL QQASMSRPLL FVVDDAQWVD GQSWDLLTTA
     ASVSSNIAVV VAHRTDAAPS HDAFKKLEMA PLTFRYELSN LSLRDTSLFL SHRYGIAIMN
     SYLLEFVHGR AHGNPRDTIT LMERLLEVEA IEIDVTRGVC HVHKDVHEVD MEVSVQTRAK
     VMYHYDSLSM ISQLALRIAS VGLEYVSLDC LSFVLRTVFQ LEADSSFAPK ASYDGSVHSG
     GSTRLLAQTV TIQALSGLGP LEAAGILKLD KHNETIEYTS SEARTVVYNV MLPSQREVIH
     KVFANWFEYE VPSHRLPRFQ YYSHLAYHQS RCRMYTDAMD HYCRGAEEAL LRGVSDYALT
     CLTSAGDVLA LTDATLGGSG SSGRHLALVG SSDRHAARRL SRLSRGPSLH FASNDERITL
     HQCKIEYLTG LVMVQKSEWT AAIEHFQATV AIYEHLVSGR PKPTTWRIPA FLHFPRFSKL
     LFCRSSPVGP FQHPPTTALA DQVEAYVRVA KALAAQIVAA EAAREKASNA IRLLGLRSIF
     SAKPPSGTTS EATFVAFLPG RKPRQKLQRN IKMDLSTEAS SRRKLPIKLL SQSHLFSSKR
     GLLAPAVVSP SDDRGSTKIP PSMVPPSSEL MDQRLASTKV APPLASDVDA ALAPLLPIER
     RAPV
//