ID A0A067CVI5_SAPPC Unreviewed; 1141 AA.
AC A0A067CVI5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=SPRG_02069 {ECO:0000313|EMBL:KDO33260.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO33260.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO33260.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO33260.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
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DR EMBL; KK583193; KDO33260.1; -; Genomic_DNA.
DR RefSeq; XP_012196016.1; XM_012340626.1.
DR AlphaFoldDB; A0A067CVI5; -.
DR STRING; 695850.A0A067CVI5; -.
DR EnsemblProtists; KDO33260; KDO33260; SPRG_02069.
DR GeneID; 24124638; -.
DR KEGG; spar:SPRG_02069; -.
DR VEuPathDB; FungiDB:SPRG_02069; -.
DR OMA; SEWREEI; -.
DR OrthoDB; 90565at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24161:SF85; LD20463P-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 371..403
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 453..481
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 546..578
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 584..605
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 616..648
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 707..739
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 762..884
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 127054 MW; 817217EE3B0BA064 CRC64;
MTHASPTLAR RMSSQDDTQP EEDLPSPLTT HIMLPTGCHT SFISVSTPQH GGEKRRGSMP
MLPSPQQDGW SNTPRTEDDH HFDRTLQEHM KACERTLPQL VLPMVSRVAT CIPQFAEYGN
TFVSSRMISW TVRITIVHVF ILASILIVGP EMKRKKYGDH GATCDAFLDG ITLTVYTGLA
NILLCLPAIH NSRYQLYTRE SKKTWLLTFC ELLVMAEIPY LVVQIVLHAS QGIEHSAYVG
CFHVRDDPTD IPPPWPWLIW SLLLAFLDLY VYVACWYQIT LFNRMRDVAL GQRNIIPSSH
LFTFSNPDWI NYGAHAKAIL RVKEGLYEAA KTGHMPDLLL LLDEAVALDG PCFHIKWYSN
SLRCFGQVAK SVRNPLHVAV VNGRLPVVQL LLERGFDPNA LEKIQTMSFR LSHIYAKIFN
VLIFLRSTNF ARSTSTNARY GPSQPWSQVL LAPLHVALIH ADAAIVETLV KFGADPNLVA
VSNQRKYKTP PLYYAECPNC LRALMRAGAN HLHIPGNGFY LTAYEVIVLN GHFSLANALV
EWGGDIALTP MHLAAANGDW RTVGHFLDAG VDPDILGENS CGRFHRTPLH WAAMRGQLRV
VKLLLAHCKE DPSDTLGMTP LAWAAIYNHY DVVEALLLAE ADPNMVDIYG RSLIHLLGHY
ETVKNQPRDR AFEGSPRQQH LETTPRGRIL YLLRSYGAKI HAKTTTTGET ALHLALKRGN
VKTARILVQM GLDVIATDNA GVRALDCASS SAIQYEIKKA AGQRDVMISY CHSHASFANK
IRSSLEAQFI TTWIDQMNPT GISGGSEWRE EIARGILGAS VVLAVLSEDY PASQWCMKEL
AFAKQHNIPV VGITCGRVVI GDELEVYLWT RQLVDFRPAI TAKFRSGNAV RFDYNEAKYE
VQLALLLDGL RDEIEERRVE LKTDDLRVSN ASGHSSCALS QHAGGSAASY VLLVHGDCHK
PFASSLKAEL LTAGVDCKID GPCPQRQVVM KDAILDPRCL AVIVVLSHLS TKSETLRDTL
AFAENRSKPI IPIMLSLQAL DNALVYSLSR TAVHHFNESI GFRESLERLL PHVRQLQLKQ
DGTSTSALPT TPPPQLPLPQ SSTKTLRRFL RRLNTQESEL ESIIDVVPSP TESLRSHHSA
L
//
