ID A0A067D299_SAPPC Unreviewed; 1470 AA.
AC A0A067D299;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=SPRG_02568 {ECO:0000313|EMBL:KDO32876.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO32876.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO32876.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO32876.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005601}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK583194; KDO32876.1; -; Genomic_DNA.
DR RefSeq; XP_012196527.1; XM_012341137.1.
DR STRING; 695850.A0A067D299; -.
DR EnsemblProtists; KDO32876; KDO32876; SPRG_02568.
DR GeneID; 24125116; -.
DR KEGG; spar:SPRG_02568; -.
DR VEuPathDB; FungiDB:SPRG_02568; -.
DR OMA; LFELHAV; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0032574; F:5'-3' RNA helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18038; DEXXQc_Helz-like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR049080; MOV-10-like_beta-barrel.
DR InterPro; IPR026122; MOV-10/SDE3_DEXXQ/H-box.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF322; RNA HELICASE MOV10L1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF21634; MOV-10_beta-barrel; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT DOMAIN 175..349
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT REGION 674..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1448..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1352
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1470 AA; 159945 MW; 39C8155CAE12A174 CRC64;
MAAKACVDAL CTYVQARHGY VRVAELESFY SSTKARKKLK ATVADAGGIE AFIAAHGASA
AYPLAVVAHA IQFAATSEAI KALGEAALPN RTTTDIGCFL GGFRKAHPAY GFMWSSAKIA
SCTEFIEIHG CLGQFQLVIV GDKKLLGITW TQQPGSPPPT TSPSASTTAT PPAAYKYITT
VQGAKQAFAV LKQSDVLFMD LEGDLEAAGK MSLLQVSCRS DCVYILDVYV CPAILREPEI
VAVLTSKLAV LHDARHDYTG LAGQFNLRLT NLFDTQVAHQ VLTSSPNTLV GLNKILHQYA
GAINTQKDSV QHGFGLWDRR PIEAQRLDYA AQDVKHLPAA YARMKSLMTT AMYNEVLAKS
LARAQLGAVP QGAHDAIRRL GKYIVSLGGK LRFSNMGDYY TKHPNDKGVF KPSLAAFLRT
HGPQASPPIL VDNDFAWVEN DSKPLTVASV LKIVGGFIAE NGGRIPGSRL GDLYKEYPGI
SAVIYANGSN ASGFVKDHGA SATPPIRSTD GDFFVGGASH EAASPANDPS PAKLLKLYGA
KFTADKYGVE IKDNNVFRRV VETKTSATQL YTVTSRATES ITLRRVFQVA TSKGSTPFKF
GPKIGTNIAF APNTTLNIPC HFSPKVPGQY KTILAFEFVT RHGTVFFIGR VVEGVNAVDA
GMDAETRDAI ASAPVKRQRR KKRTNLHFVP PTGGDKHSAK STRSKRSVPL APYPVPSPLP
VVDFEGPLSL VNYQARFRHL LFHEELEHLR QQAEFDMDGA RLKVKTPDLY ELAVPGLAEG
RPSLMTGDKV WLSRGAKTFQ GTVYDVRLDA IYIATPTSFR SAYQASASFN VRFIMSRTPM
REMHQGLASI SLAMHETLLF PSPTVPRPVE IQRSLQPTRS INPEQHKVIN DVLDHVMSSA
KVKAPYLLFG PPGTGKTVTL VETIVQLLRA KPDAKILVCA PSNAAADNVV ERLASQLTRA
KLLRAMAFSR REKGTPDAVL PFTKTNGEGG FTPVTLGDVQ AVAVIVSTIG SGAKLYNLGV
ARGYFSLIAI DEAAQASEPE VVTVLGPLAL PATVVVLAGD PKQLGPVVKS AVAAKHGLGM
SLMERLMERE LYATSHKTKL LRNYRSHDAI LTVPNELFYE GELTPHAPKA TTHNMLAWPS
LPNAAAPILF HGITGAEMQD ADSPSWYNLF ELHAVLTYIQ SLKTYPGLRL DEIGVITPYA
KQRQKIQMAL QKHKLDGVLV GSVEQFQGGE RRVILVSTVR SSTEFFADDA KFRLGFVSHP
KRFNVAITRA KALLIVVGNP DILETSSTWG PFLEHCVRLG AIAGAPPRHA TAIIKAERAN
DSGNDSDADD DDDDDEYGGN DSDDDDDDYD SDDDVCVQYE IMMAEAAAAH RANVQAEAAA
RAAQVEEERA YQARLRAWED ARARELAPRD QARRRDVYNA VMEQQYRAQL EHEERMYRSV
QAQEHAAMMA AQEAARQAKH DESTSGCSIQ
//
