ID A0A067DJ08_CITSI Unreviewed; 1223 AA.
AC A0A067DJ08;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=CISIN_1g000922mg {ECO:0000313|EMBL:KDO42838.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO42838.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO42838.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; KK785430; KDO42838.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067DJ08; -.
DR PaxDb; 2711-XP_006494027-1; -.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF580; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 64..230
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1223 AA; 138943 MW; 7E6AF3D15A748BA3 CRC64;
MDKFGGLSTM DPCRRYKIRA AVRKHEGKVT ESQLSTLKNL CCFGNKVLKI SFMAASSSCL
AAQCKYDVFV SFRGEDTRDN FTSHLVAALC RKKIKTFIDE QLDRGDDISP ALLDAIERSK
ISVIIFSENY ASSKWCLDEL VKILECKNKN AQMVVPVFYH VDPSDVRKQT GSFGDAFVKH
EKQFKGIPEK VQKWRVVLTE ASNLSGWDSM NIRPEAKLVD EIIEDILKKL KDKSFSSDFE
GLVGIYSRIE QIKSLLCVGL PDFQIIGIWG MGGIGKTTIA GAIFNQISND FEGRCFMANV
REESERGGLV YLRERLYSEI LEETLKIRTP SVPKCIKERL QQMKVFVVLD DVNKPEQLDY
LAGGLDRFGL GSRVVVTSRD RQVFDKCRVD KIYEVEGLNQ NEALEHFSNY AFRQNICPKD
FLVLSERIVF YANGNPLALK VLGSFLQRKC KLQWENALKN LTRISDPDIY DMLKISYNEL
KQEEKSIFLD IACFFKGDDK DFMTRIQDDP ESVHYGLNVL VDKSLVALSC NNKLQIHDLL
QEFGREIVRQ QSVKEPGKRS RLWYYEDVYQ VLKKNKGTES IEGMFLDVSQ IEDLHLTSRA
FVKMPNLRLL KFYVPGQITG SDMCTKVHLQ QGLQYLPDEL RYFHWYGYPL KALPFDFSPE
NLIELNLPHS KVEQIWEGKK HFNNLVMLCL SHCESLRCFP QNIHFRTLIE IDFSYCINLT
EFPEISGNVI ELDLKGTAIE EIPSSIECLT KLEELDLAYC RRLKSLPSSI CKLKSLHLLC
LYNCSNFEIF PEILEKMECL EYIDLESTAV KELPSSVEQL KGLRELILED CSELSKLPEN
LGNLKSLKRL FAKRSAISKL PSSIAYLDEV IELSFHGCRG LVLPPILSGL SSLTKLDLSD
CDVMEIPQDI GRASSLEILD ISGNDFDSLP ASIKQLSRLR ELYLSNCSML QSLPELPLRV
KLLDASNCKQ LQSLPELPSC LEELPISILE MTSKHSLGST QFKILADPCM ELTFTDCLKL
NEKGNNILAD LRLIILHMAI ASLRLFSEKE FKKPHGISIF LPGSGIPDWF SNQGSGSSIT
IQLSQHCCST NLIGFSVCAV IEYEDDFPNG GGYFNVGCSY CFEITALSET KHDDFWYLGN
QVSTCSDHIY IGFRPCINFG LPDGISVSFH FFTYNLFTNN ENGHKVKSCG VCPVYAHPNQ
TKLNTFTINM LPPSEEECDE IRK
//
