ID A0A067E9Y5_CITSI Unreviewed; 1377 AA.
AC A0A067E9Y5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=tripeptidyl-peptidase II {ECO:0000256|ARBA:ARBA00012462};
DE EC=3.4.14.10 {ECO:0000256|ARBA:ARBA00012462};
GN ORFNames=CISIN_1g000645mg {ECO:0000313|EMBL:KDO52024.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO52024.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO52024.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal tripeptide from a polypeptide.;
CC EC=3.4.14.10; Evidence={ECO:0000256|ARBA:ARBA00001910};
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; KK785043; KDO52024.1; -; Genomic_DNA.
DR STRING; 2711.A0A067E9Y5; -.
DR MEROPS; S08.A56; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008240; F:tripeptidyl-peptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04857; Peptidases_S8_Tripeptidyl_Aminopeptidase_II; 1.
DR Gene3D; 1.25.40.710; -; 1.
DR Gene3D; 2.60.40.3170; -; 1.
DR Gene3D; 6.10.250.3080; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034051; TPP_II_domain.
DR InterPro; IPR046939; TPPII_C_sf.
DR InterPro; IPR048384; TPPII_GBD.
DR InterPro; IPR048383; TPPII_Ig-like-1.
DR InterPro; IPR022229; TPPII_Ig-like-2.
DR InterPro; IPR046940; TPPII_Ig-like_sf.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR PANTHER; PTHR43806:SF14; TRIPEPTIDYL-PEPTIDASE 2; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF12580; TPPII; 1.
DR Pfam; PF21316; TPPII_GBD; 1.
DR Pfam; PF21223; TPPII_Ig-like-1; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 116..579
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 612..733
FT /note="Tripeptidyl-peptidase II first Ig-like"
FT /evidence="ECO:0000259|Pfam:PF21223"
FT DOMAIN 752..836
FT /note="Tripeptidyl-peptidase II galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21316"
FT DOMAIN 882..1067
FT /note="Tripeptidyl peptidase II second Ig-like"
FT /evidence="ECO:0000259|Pfam:PF12580"
FT REGION 1263..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 216..273
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 125
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 352
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 538
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1377 AA; 151668 MW; B4855D69BAB18C55 CRC64;
MQCHRPLFNV SSTCRAQTTP SRASSSSFST RRTLTLSSLL ITTKKLRPKR RLKFRCKLNK
SMPLSSSTGG AGGGDGDGNG SLRRFKLNES TFLASLMPKK EIGADRFVEA NPQFDGRGVV
IAIFDSGVDP AAAGLQVTSD GKPKILDVID CTGSGDIDTS TVIKADSDGC IRGASGATLV
VNSSWKNPSG EWHVGYKLVY ELFTESLTSR LKSERKKKWE EKNQEAIAKA VKHLDEFNQK
HKKVEDGKLK RVREDLQNRV DILRKQAESY DDKGPVVDAV VWHDGEVWRV ALDTQSLEDE
PDHGKLADFA PLTNYKTERK HGVFSKLDAC TFVANVYDEG NVLSIVTDSS PHGTHVAGIA
TAFNPEEPLL NGIAPGAQLI SCKIGDTRLG SMETGTGLTR AFIAAVEHKC DLINMSYGEP
TLLPDYGRFI DLVNEAVNKH RLVFVSSAGN SGPALNTVGA PGGTSSSIIA VGAYVSPAMA
AGAHCVVEPP SEGLEYTWSS RGPTADGDLG VCISAPGGAV APVSTWTLQR RMLMNGTSMA
SPSACGGIAL LISAMKANAI PVSPYTVRKA VENTSVPIGA LAEDKLSTGH GLLQVDKAYE
YVQQYGNVPC VSYQIKINQS GKLTPTYRGI YLRDAGASQQ STEWTVQVEP KFHEDASNLE
ELVPFEECIE LHSTDKAVLR APEYLLLTHN GRSFNVVVDP TNLEDGLHYY EIYGIDCKAP
GRGPLFRIPV TIIKPTAVVK RPPLVSFSRM SFLPGQIERR FIEVPLGATW VEATMRTSGF
DTTRRFFVDT VQVCPLQRPL KWENVVTFSS PVSKNFAFPV VGGQTMELAI AQFWSSGMGS
HETTIVDFEV AKLIEFHGIA VNKDEVLLDG SEAPVRIDAE ALLTSERLAP AAVLNKIRVP
CRPIETKLTV LPTNRDKLPS GKQILALTLT YKFKLEDGAE VKPQIPLLNN RIYDTKFESQ
FYMISDTNKR VYAQGDVYPD YSKLPKGDYN LQLYLRHDNV QYLEKMKQLV LFIERKLEEK
DVIRLSFFSQ PDGPIMGNGT YKSSILVPGK KEAFYLSPPG KDKLPKNSPQ GSILLGAISY
GKLSFQGQEG GKNPQKNPVS YEIAYIVPPN KLDEDKGKGS PTGTKTVSER LEEEVRDAKM
KVLGSLKQET DEECSDWKKL AASLKSEYPK YTPLLAKILE GLLSRSNVGD KIHHYEEVID
AANEVVDSID QDELAKFFSQ KSDPEDEETE KIKKKMETTR DQLAEALYQK ALAMLEIESL
KGEKSGAEAA TEGTTDVDKT SDSQPDLFEE NFKELKKWAD VKSPKYGSLL VLREKRCGRL
GTALKVLGDI IQDDSEPPKK KLYELKISLL EELGWSHLTT YEKLWMHVRF PPSLPLF
//
