ID A0A067FIT9_CITSI Unreviewed; 768 AA.
AC A0A067FIT9;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=CISIN_1g004202mg {ECO:0000313|EMBL:KDO67248.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO67248.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO67248.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003982}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK784897; KDO67248.1; -; Genomic_DNA.
DR EMBL; KK784897; KDO67249.1; -; Genomic_DNA.
DR RefSeq; XP_006483588.1; XM_006483525.2.
DR RefSeq; XP_006483589.1; XM_006483526.2.
DR RefSeq; XP_006483590.1; XM_006483527.2.
DR STRING; 2711.A0A067FIT9; -.
DR PaxDb; 2711-XP_006483588-1; -.
DR GeneID; 102609501; -.
DR KEGG; cit:102609501; -.
DR eggNOG; KOG0458; Eukaryota.
DR OrthoDB; 470716at2759; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd04093; HBS1_C_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23115:SF188; HBS1-LIKE PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120}.
FT DOMAIN 338..563
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 193..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 83571 MW; 367C94AE449C1B2A CRC64;
MPHKVNYEDY DYGDYYEYED YDDYDYDVED NGEAPTPASE SKQETSKPRV WSCAICTYDN
EEGMSVCDIC GVLRTPLVNN NRKTAGGICK DSGASVMAKS LFASLPPRTP KKAVVIQRQN
DGSLMEEGNN CHKLGNTKGK FHEFHEAFSS HSHSKFNIAP FKFDVPSPDD LVSNGLHSSK
TGSKGNFLDL KSSRVSSSVS EKNGSVNTRS SAKKSDIANV LMPKDKQDSV DERNSLKNEV
RASSRISDSS SVVMAKDRLG TIDEGNCSNH GTVDDSISSS VDGTESSSHT GNLTSNMKNM
SSTAKSGNST NVSARKTNSH TQYKPEKWML PDKKGDRMTQ LNLAIVGHVD SGKSTLSGRL
LFLLGRITQK QMHKYEKEAK LQGKGSFAYA WALDESAEER ERGITMTVAV AYFDSKNYHV
VVLDSPGHKD FVPNMISGAT QSDAAILVID ASVGSFEVGM NTAKGLTREH AQLIRSFGVD
QLIVAVNKMD AVQYSKDRFD SIKVQLGTFL RSCGFKDASL TWIPLSALEN QNLVTAPDDG
RLLSWYKGPC LLDAIDSLRP PPREFSKPLL MPICDVLKSQ HGQVSACGKL EAGALRSGLK
VLVLPSGEVG TVHSIERDSQ SCSVARAGDN IAVSLQGIDV SRVMSGGVLC HPDFPVAIAT
HLELKVLVLD FAPPILIGSQ LECHIHHAKE AARIVKITSL LDTKTGKVTK KSPRCLTAKQ
SAIVEVALQE PVCVEEFSNC RALGRAFLRS SGRTIAVGIV TRIIEDQQ
//
