ID A0A067FKS1_CITSI Unreviewed; 1866 AA.
AC A0A067FKS1;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=CISIN_1g000202mg {ECO:0000313|EMBL:KDO64052.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO64052.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO64052.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KK784909; KDO64052.1; -; Genomic_DNA.
DR RefSeq; XP_006478610.1; XM_006478547.2.
DR PaxDb; 2711-XP_006478610-1; -.
DR eggNOG; KOG4658; Eukaryota.
DR OrthoDB; 2916016at2759; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF580; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 3.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..177
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1866 AA; 212521 MW; B4C69135EF23BF37 CRC64;
MASSSSSPPR NDKKMYDVFL SFRGEDTRDN FTSHLYSALC QNNVETFIDN DLKRGDEIPE
SLLGTIEAST ISIIIFSEKY ASSKWCLDEL LKILECKRNY GQIVIPVFYR VDPSHVRKQI
GSFGDSFFML EERFPYKMRN WRSALTEAAD LSGFDSCVIR PESRLVADIA NEVLERLDDT
FQSESKDLIG VEWRIKEIES LLRTGSAGVY KLGIWGIGGI GKTTIAGAVF NKISRHFEGS
YFACNVRAAE ETGRLDDLRK ELLSKLLNDR NVKNFQNISV NFQSKRLARK KVLIVFDDVN
HPRQIELLIG RLDRFASGSQ VIITTRDKQV LTNCEVDHIY QMKELVHADA HKLFTQCAFR
GDHLDAGYTE LAHKALKYAQ GVPLALKVLG CYLCGRSKEE WESAMRKLEI VPHMEIQEVL
KISYDSLDDS QKRMHDLLRA MGREIVRKES IVDPGKRSRL WHDEDIYEVL KKNTGTEAIK
DISLNMSDNE KEIFARTFST MTNLGHLKAY ESREIKDVMS DLEVVPFPEV YAKNLVSLKM
WDGKVKERWD DVQKVDVECD RLDSHARAYW NHTDLKQLRL KLAEVRYLLQ DAVRCGADQN
LNIDTWFKDL RGLTYEVDEL IDNWEQSEIS KSMFDREIRR IHQQLVRLLN LFHKLATGHY
EESSAVSELS SRRSDDYAVS ENDLAVSERD LVHFINKVNY ELLRDVNMVR ILPISGMSGT
GRTVLAQRVY SNKKVKSHFP FRFWFSVSKN LDLSTVLNAI AVQFSEIRRA ENMADLSERL
LVVLDDVCDI DDEELHNFRL LISNMRDSGS CFLVTTHSHR VATMMSSVSE GQLISLLKLD
SEGYFKSELA PSVGAAQSPV LEHGQNLRLM TPESLVMTET QRHSTSGCKA VINSDLSGCS
VVLSESVPAS DTDSMSFLFE DPASRLENLK EDQMKYSPQP DKQAIPKGED QTNPILNICV
KQPVEPIPVI KLGTSNVTAV NYTQRNVRKI FRYVNDVTAS KIGVYGVGGI GKTAALKALI
SYPEVKVMFH VIIWVTVSRY WNTRKIQKQV LRQLSLHCKD RETDAQVAEK LWQVLNGEKF
LLLLDDVWEQ IDLEAVGIPV PGSENGSKIF MASRELDVCR NMDVNMVVKL ETLSMKDAWE
LFCKEVGGII QSPDIHLYAR AIVKGCCGLP LLTIVTAKAL AGERNVSVWK HASRKFSLPI
TIEECCTEDL IELLKFSFDQ LKDHDVKSCF LHCSLFPEDR EVSIVEFIDY CIQEGIIVGT
LANAHKRGHQ IVDVLVDASL LLINEVHNSI RMPGLMKDLA FGILSSSTGD RCFLSTAEGF
QFLSRAYSRL AELPNAGTSS LRSPERSRLF IPEAYQFLLG ARAGLTEPPS EEEWTHAKMI
FFMDNDLQTL PGRPSCPNLL TLFLQRNCRL RVIPPSFFEL MTSLKVLNLS KTRIKSLPET
LVNLKCLQIL ILRDCDFLFV LPPEVGSLEC LEVLDLRGTE IKMLPKEIGK LTSLRYLTVF
FFGSMYKSEY IKLPPDLISS DILSRLQALE TLSIDVHPGD KRWDKDVKIV ITEVSGLTKL
SSLSFHFPEI ECVAEFLKGS AWNNQQLTEF KFVVGHDVKS IVSWVTDYVQ CDYNQHDRCL
RFVNGKNVPP EVIQILIHST AFYVDHHLSI VSLSDFGVGY MSGLKFCIIS ECLKIKTVVD
TKEHTTAVFP SLENLTLNHL WDLTCIWQGI LPEGSFAELR ILSIHACRHL EYVFTCSMIQ
FLAKLEELTV EYCLAVKSII LDGEITYSSC IMLPSLKKLR LHHLPELANI WRNDWPSLEY
ISFYGCPKLK KMGMDSKLKE TLIWIKAEKK WWAELEWEDT QLPIDLGDRL SIFSEDDEDQ
EPPLCT
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