ID A0A067FRJ1_CITSI Unreviewed; 759 AA.
AC A0A067FRJ1;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=CISIN_1g004358mg {ECO:0000313|EMBL:KDO68760.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO68760.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO68760.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
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DR EMBL; KK784894; KDO68760.1; -; Genomic_DNA.
DR RefSeq; XP_006479735.1; XM_006479672.2.
DR AlphaFoldDB; A0A067FRJ1; -.
DR STRING; 2711.A0A067FRJ1; -.
DR PaxDb; 2711-XP_006479735-1; -.
DR GeneID; 102618714; -.
DR KEGG; cit:102618714; -.
DR eggNOG; KOG1131; Eukaryota.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0045951; P:positive regulation of mitotic recombination; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120}.
FT DOMAIN 7..285
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
SQ SEQUENCE 759 AA; 86073 MW; BE4AEEF5A4CB0751 CRC64;
MIFKLEDVTV YFPYDNIYPE QYSYMLELKR ALDAKGHCLL EMPTGTGKTI ALLSLITSYV
LSKPENPVKL IYCTRTVHEM EKTLAELKLL HNYQTRHLGP AAKILAIGLS SRKNLCVNSR
VLAAENRDSV DAACRKRTAS WVRALAAENP NIETCEFFEN YEKAASAAVL PPGVYTLQDL
RAFGKQQGWC PYFLARHMVQ FANVVVYSYQ YLLDPKVAGI ISKEMQKESV VVFDEAHNID
NVCIEALSVS VRRQTLEGAT RNLSRINQEI ERFKATDAGR LRAEYNRLVE GLALRGNLPI
ADAWLSNPAL PSDILKEAVP GNIRRAEHFL HVLRRLVQYL RGRLETENVE KEGPVSFVAS
ITAHAGIDQK TLRFCYERLH SLMLTLEITD TDEFLHIQTI CDFATLVGTY TRGFSIIIEP
FDERMPHIPD PVLQLSCHDA SLAVKPVFDR FQSVVITSGT LSPIDLYPRL LNFHPVVSRS
FKMSLTRDCI CPMVLTRGSD QLPVSTKFDM RSDPGVARNY GKLLVEMVSI VPDGIVCFFV
SYSYMDEIIA TWNDSGILKE IMQHKLVFIE TQDVVETTLA LDNYRKACDC GRGAVFFSVA
RGKVAEGIDF DRHYGRLVIM FGVPFQYTLS KILLARLEYL RDTFQIKEGD FLTFDALRQA
AQCVGRVIRS KADYGMMIFA DKRYSRHDKR SKLPGWILSH LRDAHLNLST DMALHIAREF
LRKMAQPYDK AGSIGRKTLL SQADLEKMTN DGSINEMLY
//
