ID A0A067FYF8_CITSI Unreviewed; 2096 AA.
AC A0A067FYF8;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=CISIN_1g000134mg {ECO:0000313|EMBL:KDO68196.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO68196.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO68196.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK784895; KDO68196.1; -; Genomic_DNA.
DR STRING; 2711.A0A067FYF8; -.
DR PaxDb; 2711-XP_006486675-1; -.
DR eggNOG; KOG0890; Eukaryota.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF72; SERINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1045..1642
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1753..2066
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2064..2096
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2096 AA; 235518 MW; CAF52D3454F94C3A CRC64;
MTESDSEILD LALRDEFDEV RAEAVISLPV IVMWSGLGVL TNVFKRLESL GKDECEKVKR
VFPISFGFLS CLSGTCSSIV DWDKNACKLL LNVEDDILSQ TVDYLLENFW CSKCDTNVVH
NQELSSKIVN PSDVQSKDLN FHSDFSFLLN IYFEFLYDES SEEVQLSCVR VIRRILVHGT
RDVLLKTRSE WIKCIEFLLL NKRKAIRDAF CTQIGYFLQD TVLSSLFLDE NASSRSNELK
LLDVIKLAFT AADDPLILET LLESTAELMM AVDVHSQHFL FLLILLVEQL DNPHVTVRMN
ASRLIRKSCF FHLKGGCELL VSKAVLICNE LFDYLSVRLA SRPIMVREFA EAAFGVETEE
LVKKMIPAVL PKLVVSQQDN DQAVNIINEL AKCLNTDMVP LIVTWIPKVL AFALHQADER
RLLSALEFYC IQTGSDNQEI FAAALPALLD ELICFVDGGD SDEINERLNR VPRVIRKVST
VLTGNEDLPG FLRNHFVGLL NSIDRKMLHA EDLSLQKQAL KRIEILIEMI GSHLTTYVPK
ILVLLMHAIN KESLQCEGLS VLHFFIEQLS RVSPSSTKHV ISQVFAALIP FLERDKDNPS
VLLNKVVKIL EDLVLKNRAI LKQHIHEFPL LPSIAALTEV NKAIQEARGP MTLKDQLLAA
VDGLNHENLN VRYMVVCELS KLLKLKSEDV TALINGEACS DLDVLSTLIS SLLRGCAEES
RTVVGQKLKL VCADCLGALG AVDPAKVKGF SCQRFKIECS DDDLIFELID KHLARAFRAA
PDTIIQDSAA LAIQELLKIA GCEASLDENV PASILQVLKD KEHLTVVASG TMGSDNIHEM
NMRGRKFWDR FSIYVKEIIA PCLTSRFQLP SGSDSVSTGP IYLPSMSFRR WIYYWIRKLT
VHATGSRASI FNACRGIVRH DMQTAIYLLP YLVLNAVCHG TEEARLGIAQ EILSVLDAAA
SDHSGASVHG ISGQSEVCIQ AIFTLLDNLG QWVDDVKQEL ALSESLTSKQ QGSKSKHPAS
SMHQDQLLTQ CQYVSGLLSA IPKVTLARAS FRCQAYARSL MYFESHVREK SGSFNPAAEK
SGTFEDEDVS FLMEIYSFLD EPDGLSGLAR LHKSLSLQDE LLSNKKSGNW AEVFTSCEQA
LQMEPTSVQR HSDVLNCLLN MCHLQAMVTH VDGLISRIPQ YKKTWCMQGV QAAWRLGRWD
LMDEYLSGAD EEGLLCSSSE SNASFDMDVA KILQAMMKKD HFSVSDKIGV SKQVLIAPLA
AAGMDSYTRA YPFIVKLHLL QELEDFHAIL VNDSFLEKSF LPSDLKFSKL MANWENRLKY
TQPSLWAREP LLAFRRMVFG ASGLGAEVGN CWLQYAKLCR LAGHYETATR AILEAQASGA
PNVHMEKAKL LWSTRRSDGA IAELQQNLLN KPVEVVGSTA ISSITSLSLV PLNPLPVLSN
TQTLNEKRDI AKTLLLYSRW IHYTGQKQKE DVITLYSRVR ELQPMWEKGY FYMAKYCDDV
LVDARKRQEE NSEIGPSEKR WWFYVPDVLL FYAKGLHRGH KNLFQALPRL LTLWFDFGSI
CQRAGSSSNK DLKNVNGKVM SIMRGCLKDL PAYQWLTVLP QLVSRICHQN EEIVRLVKHI
ITSVLRQYPQ QGLWIMAAVS KSTIPSRREA AAEIIQAAKK GSAHGNSANN LFGQFTSLID
HLIKLCFHAG QSKSRTINIS TEFSALKRMM PLGIIMPIQQ SLTVTLPPQD ANLTESPSSD
IFSASDLPTI SGIADEAEIL SSLQRPKKIV LLGSDGIKRP FLCKPKDDLR KDSRMMEFTA
MINRLLSKYP ESRRRKLYIR TFAVIPLTED CGMVEWVPHT RGLRNILQDI YISCGKFDRQ
KTNPQIKRIY DQFQGKIPED EMLKTKILPM FPPVFHKWFL TTFSEPAAWF RARVAYAHTT
AVWSMVGHIV GLGDRHGENI LFDSTTGDCV HVDFSCLFDK GLLLEKPELV PFRLTQNMID
GLGITGYEGT FLRVCEITLS VLRTHRETLM SVLETFIHDP LVEWTKSHKS SGVEVENPHA
QRAISNIEAR LQGSVVGVGA APSLPLAVEG QARRLIAEAV SHKNLGKMYI WWMPWF
//
