ID A0A067FYS6_CITSI Unreviewed; 249 AA.
AC A0A067FYS6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=cysteine dioxygenase {ECO:0000256|ARBA:ARBA00013133};
DE EC=1.13.11.20 {ECO:0000256|ARBA:ARBA00013133};
GN ORFNames=CISIN_1g023638mg {ECO:0000313|EMBL:KDO72508.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO72508.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO72508.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+);
CC Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20;
CC Evidence={ECO:0000256|ARBA:ARBA00024284};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20442;
CC Evidence={ECO:0000256|ARBA:ARBA00024284};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: Belongs to the cysteine dioxygenase family.
CC {ECO:0000256|ARBA:ARBA00006622}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK784887; KDO72508.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067FYS6; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0017172; F:cysteine dioxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070483; P:detection of hypoxia; IEA:UniProt.
DR CDD; cd20289; cupin_ADO; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR012864; PCO/ADO.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR22966:SF1; PLANT CYSTEINE OXIDASE 2; 1.
DR PANTHER; PTHR22966; UNCHARACTERIZED; 1.
DR Pfam; PF07847; PCO_ADO; 2.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120}.
FT REGION 112..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 249 AA; 25940 MW; 01652260496E7CCC CRC64;
MGIFCLPPSG VIPLHNHPGM TVFSKLLFGT MHIKSYDWVV DVPSDTSADA AGVPGKTSAV
AVDAIPGETS AAAVDIIPGK PLAAMVDVIP GKPLAAAVDA VPDKNSADVV NDNGNTSADA
VDVPSKMSTD ANPSETKKPG VRLAKVKADS DLTAPCNTSI LYPADGGNMH CFTAVTACAV
LDVLGPPYSD SEGRHCTYYQ DFPFANFSVD GASVPEEEKE GHAWLQEGEK PKDLLVIGSF
YIGPEIVEN
//
