ID A0A067GM80_CITSI Unreviewed; 445 AA.
AC A0A067GM80;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=W2 domain-containing protein {ECO:0000259|PROSITE:PS51363};
GN ORFNames=CISIN_1g013311mg {ECO:0000313|EMBL:KDO80833.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO80833.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO80833.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family.
CC {ECO:0000256|ARBA:ARBA00010397}.
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DR EMBL; KK784876; KDO80833.1; -; Genomic_DNA.
DR RefSeq; XP_006472693.1; XM_006472630.2.
DR AlphaFoldDB; A0A067GM80; -.
DR STRING; 2711.A0A067GM80; -.
DR PaxDb; 2711-XP_006472693-1; -.
DR GeneID; 102606845; -.
DR KEGG; cit:102606845; -.
DR eggNOG; KOG2767; Eukaryota.
DR OrthoDB; 5475947at2759; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0071074; F:eukaryotic initiation factor eIF2 binding; IBA:GO_Central.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR CDD; cd11561; W2_eIF5; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.20.25.350; -; 1.
DR Gene3D; 3.30.30.170; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23001; EUKARYOTIC TRANSLATION INITIATION FACTOR; 1.
DR PANTHER; PTHR23001:SF52; EUKARYOTIC TRANSLATION INITIATION FACTOR 5-2-RELATED; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100966; Translation initiation factor 2 beta, aIF2beta, N-terminal domain; 1.
DR SUPFAM; SSF75689; Zinc-binding domain of translation initiation factor 2 beta; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120}.
FT DOMAIN 289..445
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 149..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 48904 MW; A59119DC1D2A2CC1 CRC64;
MALQNIGASN SDDAFYRYKM PKMITKIEGR GNGIKTNVVN MVDIAKALAR PPSYTTKYFG
NELGAQSKFD EKTGTSLVNG AHDTAKLAGL LENFIKKYVQ CYGCGNPETD IIITKTQMVN
LKCAACGFVS EVDMRDKLTT FILKNPPVQK KTSKDKKSLR RAEKERLKEG EAADEELKKI
KKEAGKKKGS SANSKDVTAK GASTKKKAHS SDDDHSPSRS QADENEPAID DADDDDDIQW
QTDTSLEAAK QRIQEQLSSV TADMVMLSTT EEKKKSGKKS PDRESKGHEN GASGPNTHLA
DQMKDFLKKG ASASQFKSFL GSLSGTPQEV MDALFVALFD GIEKGFAKEV TKKKNYLAAA
TQEEGSQMVL LHSLESFCGK ARPAAVKEVA LVLKALYDND LLEEEFILDW YQKGLGGANK
NSQVWKNAKP VIEWLQNAES ETEED
//
