ID A0A067H7P6_CITSI Unreviewed; 869 AA.
AC A0A067H7P6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=[Histone H3]-lysine(27) N-trimethyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CISIN_1g002895mg {ECO:0000313|EMBL:KDO86985.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO86985.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO86985.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; KK784873; KDO86985.1; -; Genomic_DNA.
DR RefSeq; XP_015380677.1; XM_015525191.1.
DR AlphaFoldDB; A0A067H7P6; -.
DR STRING; 2711.A0A067H7P6; -.
DR GeneID; 102606927; -.
DR OrthoDB; 902834at2759; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0046976; F:histone H3K27 methyltransferase activity; IBA:GO_Central.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0031507; P:heterochromatin formation; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10519; SET_EZH; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF14; HISTONE-LYSINE N-METHYLTRANSFERASE EZA1; 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS51576; SAM_MT43_EZ; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 602..706
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 720..835
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 97507 MW; ABB644CDB3B07818 CRC64;
MVSRASDSSS KSRKSYSEQS NDGLGNLTYK LNQLKKQVQA ERVVSVKDKI EKNRKKIEND
ISQLLSTTSR KSVIFAMDNG FGNMPLCKYS GFPQGLGDRD YVNSHEVVLS TSSKLSHVQK
IPPYTTWIFL DKNQRMAEDQ SVVGRRRIYY DQHGSEALVC SDSEEDIIEP EEEKHEFSDG
EDRILWTVFE EHGLGEEVIN AVSQFIGIAT SEVQDRYSTL KEKYDGKNLK EFEDAGHERG
IALEKSLSAA LDSFDNLFCR RCLLFDCRLH GCSQTLINPS EKQPYWSEYE DDRKPCSNHC
YLQSRAVQDT VEGSAGNISS IITNTEGTLL HCNAEVPGAH SDIMAGERCN SKRVLPVTSE
AVDSSEVAIG NENTDTSMQS LGKRKALELN DSVKVFDEIE ESLNKKQKKL LPLDVLTASS
DGIPRPDTKS GHHVGAINDN ELQMTSKNTI KKSVSAKVVS HNNIEHNIMD GAKDVNKEPE
MKQSFSKGEL PEGVLCSSEW KPIEKELYLK GVEIFGRNSC LIARNLLSGL KTCMEVSTYM
RDSSSSMPHK SVAPSSFLEE TVKVDTDYAE QEMPARPRLL RRRGRARKLK YSWKSAGHPS
IWKRIADGKN QSCKQYTPCG CQSMCGKQCP CLHNGTCCEK YCGYSFLRCS KSCKNRFRGC
HCAKSQCRSR QCPCFAAGRE CDPDVCRNCW VSCGDGSLGE PPKRGDGQCG NMRLLLRQQQ
RILLAKSDVA GWGAFLKNSV SKNDYLGEYT GELISHREAD KRGKIYDRAN SSFLFDLNDQ
YVLDAYRKGD KLKFANHSSN PNCFAKVMLV AGDHRVGIFA KEHIEASEEL FYDYRYGPDQ
APAWARKPEG SKREDSSVSQ GRAKKHQSH
//
