ID A0A067HB85_CITSI Unreviewed; 1296 AA.
AC A0A067HB85;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=CISIN_1g000762mg {ECO:0000313|EMBL:KDO85102.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO85102.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO85102.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; KK784874; KDO85102.1; -; Genomic_DNA.
DR RefSeq; XP_006473796.1; XM_006473733.2.
DR STRING; 2711.A0A067HB85; -.
DR PaxDb; 2711-XP_006473796-1; -.
DR GeneID; 102618032; -.
DR KEGG; cit:102618032; -.
DR eggNOG; KOG1933; Eukaryota.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1296
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001638437"
FT TRANSMEM 291..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 844..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1120..1143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1150..1170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1182..1202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1214..1237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1249..1276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 632..795
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1296 AA; 143058 MW; FABAF48936C7ACC8 CRC64;
MKLSRRKIKF LQSISLFQVL FILCVVRAER PDARLLATSN SVAGEVKHVE EFCAMYDICG
ARSDRKVLNC PYNIPSVKPD DLLSSKVQSL CPTITGNVCC TEDQFDTLRT QVQQAIPFLV
GCPACLRNFL NLFCELTCSP NQSLFINVTS VSKVSNNLTV DGIDYYITDT FGQGLYESCK
DVKFGTMNTR ALDFIGGGAQ NFKDWFAFIG RRAAANLPGS PYTIKFWPSA PELSGMIPMN
VSAYSCADGS LGCSCGDCTS SPVCSSTAPP PHKSSSCSVK MGSLNAKCVD FALAILYIIL
VSLFFGWGFF HRKRERSRSF RMKPLVNAMD GSELHSVERQ KEENLPMQVQ MLGTPRTRNR
IQLSIVQGYM SNFYRKYGKW VARNPTLVLS LSMALVLLLC LGLIRFEVET RPEKLWVGPG
SRAAEEKLFF DSHLAPFYRI EELILATIPD TTHGNLPSIV TESNIKLLFE IQKKIDGLRA
NYSGSMISLT DICMKPLGQD CATQSVLQYF KMDPKNFDDF GGVEHVKYCF QHYTSTESCM
SAFKGPLDPS TALGGFSGNN YSEASAFVVT YPVNNAVDRE GNETKKAVAW EKAFVQLAKD
ELLPMVQSKN LTLAFSSESS IEEELKREST ADAITIVISY LVMFAYISLT LGDTPHLSSF
YISSKVLLGL SGVVLVMLSV LGSVGFFSAI GVKSTLIIME VIPFLVLAVG VDNMCILVHA
VKRQQLELPL ETRISNALVE VGPSITLASL SEVLAFAVGS FIPMPACRVF SMFAALAVLL
DFLLQITAFV ALIVFDFLRA EDKRVDCIPC LKLSSSYADS DKGIGQRKPG LLARYMKEVH
ATILSLWGVK IAVISLFVAF TLASIALCTR IEPGLEQKIV LPRDSYLQGY FNNISEHLRI
GPPLYFVVKN YNYSSESRQT NQLCSISQCD SNSLLNEISR ASLIPQSSYI AKPAASWLDD
FLVWISPEAF GCCRKFTNGS YCPPDDQPPC CPSGQSSCGS AGVCKDCTTC FHHSDLLKDR
PSTIQFKEKL PWFLNALPSA SCAKGGHGAY TNSVDLKGYE NGIVQASSFR TYHTPLNRQI
DYVNSMRAAR EFSSRVSDSL QMEIFPYSVF YMYFEQYLDI WRTALINLAI AIGAVFVVCL
ITTCSFWSSA IILLVLTMIV VDLMGVMAIL KIQLNAVSVV NLVMAVGIAV EFCVHITHAF
SVSSGDKNQR MKEALGTMGA SVFSGITLTK LVGVIVLCFS RTEVFVVYYF QMYLALVLLG
FLHGLVFLPV VLSVFGPPSR CMLVERQEER PSVSSL
//
