ID A0A067HG45_CITSI Unreviewed; 1162 AA.
AC A0A067HG45;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=CISIN_1g000778mg {ECO:0000313|EMBL:KDO87012.1};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:KDO87012.1, ECO:0000313|Proteomes:UP000027120};
RN [1] {ECO:0000313|EMBL:KDO87012.1, ECO:0000313|Proteomes:UP000027120}
RP NUCLEOTIDE SEQUENCE.
RG International Citrus Genome Consortium;
RA Gmitter F., Chen C., Farmerie W., Harkins T., Desany B., Mohiuddin M.,
RA Kodira C., Borodovsky M., Lomsadze A., Burns P., Jenkins J., Prochnik S.,
RA Shu S., Chapman J., Pitluck S., Schmutz J., Rokhsar D.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK784873; KDO87012.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067HG45; -.
DR Proteomes; UP000027120; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd20404; Tudor_Agenet_AtEML-like; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000027120}.
FT DOMAIN 1108..1124
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..72
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..196
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 129095 MW; EF0FA6DBDEFF78B2 CRC64;
MAPGKRQNNG RSPLVNPQRQ ITSFFSKSNS PSPSPTISKL NPNKSNSNPN PNPNSNSNRT
PSPSPSPTTP SPLQSNPKKS RLVIGQTPSP PPSTPAAAKS YGEDVLRKRI RVYWPLDKAW
YEGCVKSFDK ECNKHLVQYD DGEDELLDLG KEKIEWVQES VSLLKRLRRD SFKKVVVEDD
EEMENVEDEI SDDRSDSSDD DWNKNVGKED VSEDEEVDLV DEQENKVLRG RKRKSSGVKK
SKSDGNAVNA DFKSPIIKPV KIFGSDKLSN GFDNPVMGDV SERFSAREAD KFHFLGPDRR
DAKRRRPGDV YYDPRTLYLP PDFLRNLSEG QKQWWEFKSK HMDKVIFFKM GKFYELFEMD
AHVGAKELDL QYMKGEQPHC GFPERNFSMN VEKLARKGYR VLVVEQTETP EQLELRRKEK
GSKDKVVKRE ICAVVTKGTL TEGELLSANP DASYLMALTE SNQSPASQST DRCFGICVVD
VATSRIILGQ VMDDLDCSVL CCLLSELRPV EIIKPANMLS PETERAILRH TRNPLVNDLV
PLSEFWDAET TVLEIKNIYN RITAESLNKA DSNVANSQAE GDGLTCLPGI LSELISTGDS
GSQVLSALGG TLFYLKKSFL DETLLRFAKF ELLPCSGFGD MAKKPYMVLD APALENLEVF
ENSRSGDSSG TLYAQLNHCV TAFGKRLLRT WLARPLYNSG LIRERQDAVA GLRGVNQPFA
LEFRKALSRL PDMERLLARL FASSEANGRN SNKVVLYEDA AKKQLQEFIS ALHGCELMDQ
ACSSLGAILE NTESRQLHHI LTPGKGLPAI VSILKHFKDA FDWVEANNSG RIIPHGGVDM
DYDSACKKVK EIEASLTKHL KEQRKLLGDT SITYVTIGKD LYLLEVPESL RGSVPRDYEL
RSSKKGFFRY WTPNIKKLLG ELSQAESEKE SALKSILQRL IGQFCEHHNK WRQMVAATAE
LDALISLAIA SDFYEGPTCR PVILDSCSNE EPYISAKSLG HPVLRSDSLG KGEFVPNDIT
IGGHGNASFI LLTGPNMGGK STLLRQVCLA VILAQVGADV PAEIFEISPV DRIFVRMGAK
DHIMAGQSTF LTELSETALM LSSATRNSLV VLDELGRGTS TSDGQAIAVF SSGFQSLAGS
QFLSTLFIKC NAVDCFQLTI TA
//
