ID A0A067KCG2_JATCU Unreviewed; 602 AA.
AC A0A067KCG2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 13-SEP-2023, entry version 41.
DE RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
GN ORFNames=JCGZ_19242 {ECO:0000313|EMBL:KDP29529.1};
OS Jatropha curcas (Barbados nut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Jatropheae;
OC Jatropha.
OX NCBI_TaxID=180498 {ECO:0000313|EMBL:KDP29529.1, ECO:0000313|Proteomes:UP000027138};
RN [1] {ECO:0000313|EMBL:KDP29529.1, ECO:0000313|Proteomes:UP000027138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. GZQX0401 {ECO:0000313|Proteomes:UP000027138};
RC TISSUE=Young leaves {ECO:0000313|EMBL:KDP29529.1};
RX PubMed=24837971; DOI=10.1371/journal.pone.0097878;
RA Zhang L., Zhang C., Wu P., Chen Y., Li M., Jiang H., Wu G.;
RT "Global Analysis of Gene Expression Profiles in Physic Nut (Jatropha curcas
RT L.) Seedlings Exposed to Salt Stress.";
RL PLoS ONE 9:E97878-E97878(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU003862};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU003862}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743, ECO:0000256|RuleBase:RU003862}.
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DR EMBL; KK914743; KDP29529.1; -; Genomic_DNA.
DR RefSeq; XP_012081878.1; XM_012226488.1.
DR AlphaFoldDB; A0A067KCG2; -.
DR STRING; 180498.A0A067KCG2; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000027138; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003862};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003862};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003862};
KW Reference proteome {ECO:0000313|Proteomes:UP000027138}.
SQ SEQUENCE 602 AA; 67510 MW; 01E58EAF1E9997B7 CRC64;
MKVIDKINAA QAVANGGGEA NNRVVFSFEF FPPKTEDGVD NLFDRMDRMV AHNPSFCDIT
WGAGGSTADL TLDIANKMQN MICVETMMHL TCTNMPVEKI DHALQTIKSN GIQNVLALRG
DPPHGQDKFV QVEGGFACAL DLVKHIRSKY GDYFGITVAG YPEAHPDMIG SDGLATPENY
QKDLEYLKRK VDAGADLIVT QLFYDTDVFL KFVNDCRQIG INCPIVPGIM PINNYKGFIR
MTGFCKTKIP AEVTAALEPI KDNEEAVRAY GIHLGTEMCK KILAHGIKTL HLYTLNMEKS
ALAILLNLGL IEESKIRRPL PWRPPTNVFR VKEDVRPIFW ANRPKSYIAR TLGWEQYPHG
RWGDSNNPSY GALTDYQFMR PRARDKKLHD EWAVPLNSIE DICEKFKKFC LGKMKSSPWS
ELDGLQPETK IINEQLGKIN MKGFLTINSQ PAVNGEKSDS LTVGWGGPGG YVYQKAYLEF
FCSPIKLQDL VNKSKAWPQL TYMAVDRAGT VVSNVGPNDV NAVTWGVFPA KQIIQPTVVD
PASFNVWKDE AFEIWSRGWA SLYPEGDPSR KLLEEVQDNY FLVSLVDNDY IHGDIFAIFA
DL
//
