ID   A0A067M516_9AGAM        Unreviewed;       943 AA.
AC   A0A067M516;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN   ORFNames=BOTBODRAFT_70681 {ECO:0000313|EMBL:KDQ06967.1};
OS   Botryobasidium botryosum FD-172 SS1.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Cantharellales; Botryobasidiaceae; Botryobasidium.
OX   NCBI_TaxID=930990 {ECO:0000313|EMBL:KDQ06967.1, ECO:0000313|Proteomes:UP000027195};
RN   [1] {ECO:0000313|Proteomes:UP000027195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FD-172 SS1 {ECO:0000313|Proteomes:UP000027195};
RX   PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA   Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA   Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA   LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA   Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA   Hibbett D.S., Grigoriev I.V.;
RT   "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT   white-rot/brown-rot paradigm for wood decay fungi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC   -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC       {ECO:0000256|ARBA:ARBA00043957}.
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DR   EMBL; KL198118; KDQ06967.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A067M516; -.
DR   STRING; 930990.A0A067M516; -.
DR   HOGENOM; CLU_010129_3_0_1; -.
DR   InParanoid; A0A067M516; -.
DR   OrthoDB; 2880475at2759; -.
DR   Proteomes; UP000027195; Unassembled WGS sequence.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   CDD; cd06147; Rrp6p_like_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   InterPro; IPR049559; Rrp6p-like_exo.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF08066; PMC2NT; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   3: Inferred from homology;
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027195};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT   DOMAIN          502..583
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   REGION          89..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        801..829
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   943 AA;  101681 MW;  4FDBB724AB3BB135 CRC64;
     MSSASSSSED EAPAVPSPIT AFAAYQAHLQ KSLIGLTKQA YALPDKDELA FQRTLDRKFG
     QGVDRCSERV LGLVNRLLVL AGGADGGSGE DGWGVTGKGK GKGKAGDRAR DEGRERVILR
     DEEDVVDGFH GNIQDVVDQL LENTDKCLDE FAGRLKPPSI PANAPVAAAH QTRVAPTGAL
     PASLKHASRL PKPQLRFSRP VDNSNVPCAR PRLKLKYHAR VPEDYQDGDA SMQDESTLAS
     THPYRFEITN LDPPSSLFTP PPTPIPPVGS FESTPFTYVT TPAQLATLLA ALKSAPEIAV
     DLEHHSYRSY YGFVCLVQIS TREQDWIVDT LVLREELECL GEVFADPQIV KVFHGAESDI
     VWLQQDFNLY IVNLFDTYHA SKVLDFPKHS LAALLSLYCD FAADKRYQLA DWRIRPLPEE
     MLFYARSDTH YLLKVYDHLR HALLQQSQSA GDPAESIKEV LSRSAQTALR VHEKEVYDPE
     GGQGANGWDV LVRKWNNGQR MGGEKGAVVR AVHAWRDRVA READESPRYV LPNHYIFQLA
     ETRTPSDVAS LLGMFSPIPH LVRERGRELL DVIKEAVARA KEDAGAGESG RATPVAAGSV
     SAGVANPRLG IAPSASMAVV EDMVMVVDEW APPEVDLWSR RGSEMDFRID AVSTPVSTLF
     GGTLSAEPLA ISPTSYVASS SVLFGPSNSS TASKILAPVE TDQRYNDIVA KIHSTLVIAP
     SIPKIKPSSA SPTDPAGTES AEGILAMPDE IAFVPLSARQ TTQSGKGKGK STAAGADEGE
     DARDAVVMVG QARQRKRKRQ AQMQIQMQQA QGNGSGAGSR ASSKQGTPVS VEGAEGADGE
     EGGRGEGAGV PQKQKKKKGG QEKGAGGKVV PEDVEPFDYA TAPNILDDEA PGVPEPQPSK
     TKKRKGNKKG EGSRTGIQSG DFPAPPKAYS EVKAGNRSQT FQR
//