ID A0A067M6M4_9AGAM Unreviewed; 1360 AA.
AC A0A067M6M4;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BOTBODRAFT_135721 {ECO:0000313|EMBL:KDQ11413.1};
OS Botryobasidium botryosum FD-172 SS1.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Botryobasidiaceae; Botryobasidium.
OX NCBI_TaxID=930990 {ECO:0000313|EMBL:KDQ11413.1, ECO:0000313|Proteomes:UP000027195};
RN [1] {ECO:0000313|Proteomes:UP000027195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD-172 SS1 {ECO:0000313|Proteomes:UP000027195};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KL198058; KDQ11413.1; -; Genomic_DNA.
DR STRING; 930990.A0A067M6M4; -.
DR HOGENOM; CLU_002081_0_0_1; -.
DR InParanoid; A0A067M6M4; -.
DR OrthoDB; 1703463at2759; -.
DR Proteomes; UP000027195; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF146; EXPRESSED PROTEIN; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000027195};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 892..912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..190
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 324..595
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 609..884
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 984..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1050
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1360 AA; 152314 MW; 84B95660C1763971 CRC64;
MADLQSRNFN VEYKGLQNQS LVSITIITLS LIGFETLRRK RRRAGARTCP GREDVASVES
WEFGYLYQAR LWAKNPSPPL PSALFGWVKQ AIQFDEAEYV KLNGMDVAVY TRFIRACVWF
LLLHTLTTLP ILLPIHLVFS PSDVPSTSMA RASLSSLVDP SNGGRGLKLL YVHVIILSWV
SVTWAFALVW LVRGVFRYRS MQIQEIVDSK PSELPTIPSD APLSDLMRHS LVTDESCRGL
RYRTVMVTNI PTELRNEKQL REYFEYYMSR TVMRAPSLVP GFASGPLSFL MNGVYRAQRR
VKKGMVEETE ATEEAKMAAI EKKKPVVDRV IVVRKMTDLA SLLDRREDVL SRLEAAHISL
AQKTLVAVKN HLDKDRQDAA RPTVSRLAAL RKVFMHTDLE KGEKGKGKTL ESEARMELLA
RALGPFAEEL GSSMYMQTRS VLVRVKDCLR TGRDFVLRRR RLGSAKNDDV HVMIPPSISH
PVSTEPLPTV WDALHALPRD YLDPYQPLIH LSYLFRGATV PSIDYYTAKL GLLTALINEQ
RARAPDDFLP VSTAFVTFRY PEDARRACRD LAAHPKNLMA CAVVPAPSYE DLDWSRLMRS
TFTGEFLKDW VVNLGVWAFT IFWVFPVSSF VTLVSITKLS TVIPALQKYL EKHQVQEQVL
SSLVPTLLVS LLAILMPLFL ILIAKKAQHI VTISKLHDCI LTRYYKFLMC NILVFFCVGT
AALGAFLQKF SQTVNPDTTL NLIAQSFPTA APFYVGWLIF EISMHSGLQI VLFGVPLFVY
PATVRGAKTP RKRAAGTRAR TFDYFYWLPN HLVVLIIAIV FTILNPLVIP FALIYFSAAL
VVFKNQFIHV YRKLFESHGV YLVIRIIRYS CDGLILAQVV LLALLLVLKK KALAGITAGV
LIVFTAAFKL IFTKFCRAQF DEMNIAEANI LCDKQPPQSL EASREELGAV ASESSESKLA
HHDSVRFWTS KFTSPWHKYQ FTSSNFKARP SPRPPISFVP TLTKSGTQSR YSMEDKERDL
ASPSATSECL ISPSAPPAPS AAPAPSTPPL RVDTQPTEIP AGLVSSHPPR APWDDSPLVD
KPYDNPFYKK AIDNVLWLPR KPWDILDLDD TVDMNKSLTS EPGTGQLGQW VEGTEESQIR
SITSDQPESP VVERAEHSPM MQRPGFPRRG LSGLEAIVLP AIIAARVDDI EEESDVEDTG
RTRSAPSIFG RRSTISSTRP SLPPRSQTHA LGVHPSSSFL YRHRSLSRSR ARAGSLGQMH
LSPASMLSVL PAAAASEVSV AGPPPSLQED GKGGVTRSVT TRQAVVGEVL AEEQVATADR
MRRERDYEPK TSSGSRSWLT AWLYQRKRRR GDQTPEEYIQ
//
