ID A0A067MNL6_9AGAM Unreviewed; 1380 AA.
AC A0A067MNL6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE AltName: Full=Mitochondrial DNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00031966};
GN ORFNames=BOTBODRAFT_175483 {ECO:0000313|EMBL:KDQ13472.1};
OS Botryobasidium botryosum FD-172 SS1.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Botryobasidiaceae; Botryobasidium.
OX NCBI_TaxID=930990 {ECO:0000313|EMBL:KDQ13472.1, ECO:0000313|Proteomes:UP000027195};
RN [1] {ECO:0000313|Proteomes:UP000027195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD-172 SS1 {ECO:0000313|Proteomes:UP000027195};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; KL198043; KDQ13472.1; -; Genomic_DNA.
DR STRING; 930990.A0A067MNL6; -.
DR HOGENOM; CLU_001524_2_0_1; -.
DR InParanoid; A0A067MNL6; -.
DR OrthoDB; 5403095at2759; -.
DR Proteomes; UP000027195; Unassembled WGS sequence.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 3.30.420.390; -; 2.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000027195};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 939..1171
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1380 AA; 153988 MW; 9EBA625796896BFC CRC64;
MRRSPLFSST VRNTRSIHTS HKRAQSSAVR RPTRGATAKE KLPNSSDAQE VDKNEVGVQL
LSRSLHSQIF RDTTFPPPDP AYVRISREHL AMHGLDPAQS SVLPNVDFTL PPLQGKNLDE
HFHRVGSQAA QPYLSLAEQF AATTLSPIPE HWEPEPGWTK YYADGSFHHV ETPGDEAMLS
FDIETMPSYH HHAVMACAAS ADAWYAWISP WLLGQSSDPK HLIPLGDPST HRVVVGHNVS
YDRARVLEEY SIHRTNNRYL DTMALHVAVN GISSHQRPAW MNFRKSRQEK MTMDEEAADA
VRAMLKTTEL DHLEEQDETK RVQLRQLRSD VEESLPQLQL DEDQVDGEES KRWEEITSAS
SLADIAFLHC GIQMDKAARS DFMTSTPEEI RADLSDYLNY CARDVEVTHA VFCKVLPSFR
QACPSPVSFA GMLSMGNSFL TVDESWETYI QSAEAKYREL EDGIRLKLVG LAEEAKDMMA
IGPVADGAPG PWENDPWLKQ LDWSPKIPGP SRGITQPSKA KSLPISRRIS AGKVPGWYHQ
IRTQDIFSGA NFRVTIPLLL RMVWNGFPMV YSSTYGWVYR VPRSHRSLAS STPLEVLPGD
ELSRLPFELA DPKQFAFLPI AGANWKEECI FDSAVGREAF RNETIKLRRA GVASLAAALF
DPVRRKGEDV AKDVLALAKK TSKGADKIGV LQAIWLKQLD WTEVDVETPA PAPLPVSPAH
SQVVWPKWYW EITAPKKDKA PGTLDITTRS KVAPLLLRLR WQNWPLFRSR EHGWLFRVPV
SEVESLKTGQ SPVTFSSEAD LLLQEQLGKG GYQFFKLPHP EGDKANVGSP LAKTFMKYAA
EGVLTSPGDD AKAALDMNAQ CSYWISVRDR VMNQMVVWED ENVKMGLGER SKAQGVVQAL
EGSKQGIILP QVVTMGTVTR RAVERTWLTA SNAKANRVGS ELKSMVRAPP GYAIVGADVD
SEELWISSVM GDAQFGVHGA TAIGWMTLEG TKAAGTDLHS KTASILGISR NQAKVFNYSR
IYGAGKKHAM LLLLQSNAAM SPKTAEKLAD DLYISTKGKK SRTDSFGRKF WHGGTESFLF
NKLEEIALSD RPQTPVLGCG ITHALSKEHL QEGFGKDFLP SRINWVVQSS GVDYLHLLIV
AMEHLIQKYQ IDARYLISVH DELRYLVREE DKYRAAMALQ VANLWTRCLF AYRLGMDDLP
QGVAFFSAVD VDHVLRKEVD MPCITPSQPN PIPPGESLDI ASLLDLTKGG SLRPNLLPME
EEDEAHLEDL GSSYRQPDCL AHRATEAAFL KAQVTQEPGE IAMLANFRGR AAAEKAAAAP
PKKQYKRRAK PSPPTHVAHP LGHESELSFV YEHDFDAEML YNAWIEEHSK QRFTKVKLGL
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