ID A0A067NU60_PLEOS Unreviewed; 668 AA.
AC A0A067NU60;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=CBS domain-containing protein {ECO:0000259|PROSITE:PS51371};
GN ORFNames=PLEOSDRAFT_1062557 {ECO:0000313|EMBL:KDQ30550.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ30550.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL198006; KDQ30550.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067NU60; -.
DR STRING; 1137138.A0A067NU60; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1062557; -.
DR HOGENOM; CLU_009026_1_1_1; -.
DR InParanoid; A0A067NU60; -.
DR OrthoDB; 1328303at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd17781; CBS_pair_MUG70_1; 1.
DR CDD; cd17782; CBS_pair_MUG70_2; 1.
DR CDD; cd06409; PB1_MUG70; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR13780; AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR13780:SF125; MEIOTICALLY UP-REGULATED GENE 70 PROTEIN; 1.
DR Pfam; PF00571; CBS; 4.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00116; CBS; 4.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 2.
DR PROSITE; PS51371; CBS; 4.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 641..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..123
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 132..190
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 240..305
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 314..371
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 71751 MW; F7F44661105D980E CRC64;
MSSISGYQGS LSEIRKKQSK RDEAIRKKIE SELSRKRTIS TTNYNGSRGK RGSKSAPAKG
TVAALKPTPA LTVPENITVA EASQLCAAKR TDCVLVVDDE EGLSGIFTAK DLAYRVTADG
LEPHTTQVHQ IMTRNPMVTR DTTSATEALQ LMVSKHFRHL PVCNEEGNVV GLLDITKVFH
EALAKVERSS AASEQLFSAM AGVQSELGGG ISANPQAAAM LAWAESLKEK TALPDLTTVM
DSRTHPATVG PKATVREVAK LMKERRTTAV CVMEAPVSSM EPAKIAGIFT SKDVVLRVIA
AGLDAGRCSV VRVMTPHPDT APPTMTVHNA LKKMHTGHYL NLPVVEEDGR LVAIVDVLKL
TYATLEQMNS MATEEPTEAE GGPMWGRFFD SIGHDDGDSA VSGSAHTPHT PDLRHMKSLS
SMHHLSHLQQ SPMSEVHPND SASVVDDEPT SVLDSFTRQK GLVIPPTTEA LPVDDGTYVF
KFRTPSGRTH RFQSRHDDVE HLREIVAGKL ATDPFFTEFR PSDGSTDHPD PIDFILSYTD
ADGDTVLITS DHDVTDAVKI ARAAGTDRVV LFVQGGKGWA EAGADKGEAK AAEAAAAAQI
ETQEVEKQES VLPEPVTLTP PAHVHVPPPP PQEVLGIPKD LLLPASIGAL AVVIIGVFAV
SRMTGSRY
//
