ID   A0A067NWQ6_PLEOS        Unreviewed;       565 AA.
AC   A0A067NWQ6;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN   ORFNames=PLEOSDRAFT_1102620 {ECO:0000313|EMBL:KDQ28577.1};
OS   Pleurotus ostreatus PC15.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX   NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ28577.1, ECO:0000313|Proteomes:UP000027073};
RN   [1] {ECO:0000313|Proteomes:UP000027073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX   PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA   Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA   Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA   LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA   Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA   Hibbett D.S., Grigoriev I.V.;
RT   "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT   white-rot/brown-rot paradigm for wood decay fungi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
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DR   EMBL; KL198007; KDQ28577.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A067NWQ6; -.
DR   STRING; 1137138.A0A067NWQ6; -.
DR   VEuPathDB; FungiDB:PLEOSDRAFT_1102620; -.
DR   HOGENOM; CLU_022435_0_0_1; -.
DR   InParanoid; A0A067NWQ6; -.
DR   OrthoDB; 1079044at2759; -.
DR   Proteomes; UP000027073; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProt.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07216; Pat17_PNPLA8_PNPLA9_like3; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR24185; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   PANTHER; PTHR24185:SF4; SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027073}.
FT   DOMAIN          231..432
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   565 AA;  62554 MW;  3FEAFF4FD51AF1B3 CRC64;
     MSFTRSDCYS VSSSSPTRAE ATSNELESKL WFKTPPLENS FLERVSCIRL QTTARDQGYV
     SFPDEGSWSW FDIAILASPE STTPLVRGGL TCLWRSHCNV IGYGKDTTTV GEVFDKEDDL
     FKVLQPGDVL AVMVCARFPG WENNASSASL EFRLEKKGHE LPVFDAAQFE EKRRMNELKK
     NIELLLTGYL DDRTDKGEKP AYSLVREMML PGEAIRGDLA RQRNGAPLRL LSIDGGGVRG
     ISSLVILENI MLKLTNDPET KPCDYFDMIC GTSTGGLIAL MLGRLRMSVP QCIEAYKRFA
     SDIFRMNGMF AKGIEEGSTG YAYGADTFES AVKAIVKQYG DGKETMIPQS PDQHCKVFVV
     AGEASNLSKT PEHLRTYKSA KFANVDKFVD IPIWQAARAT SAAPTFLPSI TINGTELIDG
     GLLYNNPIAL LLGEAYHEFG VERLMSTRCL LTLGTGHGPN LHAPPRPELG VLPSLQYHRD
     LAETLASIAT DCEHTHQKAR KVFPEDDTYW RFNYGTQNGG DWKKVLELDE WQGMEAFASG
     TRDYISSPEQ TPRAHGCASK LGVVV
//