ID A0A067NYY4_PLEOS Unreviewed; 1636 AA.
AC A0A067NYY4;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 28-JUN-2023, entry version 19.
DE RecName: Full=1,3-beta-glucan synthase {ECO:0000256|ARBA:ARBA00012589};
DE EC=2.4.1.34 {ECO:0000256|ARBA:ARBA00012589};
GN ORFNames=PLEOSDRAFT_1052138 {ECO:0000313|EMBL:KDQ33283.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ33283.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-
CC beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:21476, Rhea:RHEA-
CC COMP:11146, Rhea:RHEA-COMP:14303, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37671, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000192};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 48 family.
CC {ECO:0000256|ARBA:ARBA00009040}.
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DR EMBL; KL198004; KDQ33283.1; -; Genomic_DNA.
DR STRING; 1137138.A0A067NYY4; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1052138; -.
DR HOGENOM; CLU_000844_0_1_1; -.
DR InParanoid; A0A067NYY4; -.
DR OrthoDB; 354539at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0000148; C:1,3-beta-D-glucan synthase complex; IEA:InterPro.
DR GO; GO:0003843; F:1,3-beta-D-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006075; P:(1->3)-beta-D-glucan biosynthetic process; IEA:InterPro.
DR InterPro; IPR026899; FKS1-like_dom1.
DR InterPro; IPR003440; Glyco_trans_48.
DR PANTHER; PTHR12741:SF29; 1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED; 1.
DR PANTHER; PTHR12741; LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1; 1.
DR Pfam; PF14288; FKS1_dom1; 1.
DR Pfam; PF02364; Glucan_synthase; 1.
DR SMART; SM01205; FKS1_dom1; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KDQ33283.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 267..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1105..1125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1158..1179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1275..1293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1364..1386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1406..1430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1442..1465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1545..1564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1598..1622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..233
FT /note="1,3-beta-glucan synthase component FKS1-like"
FT /evidence="ECO:0000259|SMART:SM01205"
SQ SEQUENCE 1636 AA; 186678 MW; 10264ADC2F715E82 CRC64;
MSAEEIEDIF LDLTQKFGFQ RDSMRNMYDF LMQLLDSRAS RMTPNQALLT VHADYIGGQH
ANYRKWYFAA QLNLDDAVGQ SNNPGLQRLK SVKGGVKTGG AKSLDSALNR WRSAMNNMSH
YDRIRQLALY LLCWGEAGNV RFVPECLCFI FKCADDYYRS PECQNRVEPV REGLYLENII
KPLYRFMRDQ GYEVVDGKFV RREKDHAQII GYDDINQLFW YPEGIARIVL SDNTRLVDAA
PAQRFMKLMK VDWNRVFFKT YFEKRSIAHL LVNFNRIWVL HVAVFYFYTA FNSPKVYAPR
NKNNPSAPMT WSATALGGAV ATGIMILATL AEFSYIPTTW NNASHLTTRL IFLLVILALT
AGPTFYIAMV DGRPNQGNVP LIIGIVQFFI SAVVTVAFGI IPSGRMFGDR VRGKNRKFMA
SQTFTASYPT LPGTARSASI GIWLLIFTCK FVESYFFLTS SFSSPIAVMA RTKVQGCSDK
FFGSALCSNQ VPFALAIMYV MDLILFFLDT YLWYIIWIVV FSIGRSFSLG LSIWTPWKDI
YTRLPKRIYA KLLATAEMEV KYKPKVLVSQ IWNAVIISMY REHLLSIDNV QRLLYHQVDS
PDGRRTLRAP PFFTNQEGGN FFPSGGEAER RISFFASSLT TALPEPLPVD AMPTFTVLVP
HYSEKILLSL REIIREEDQN TRVTLLEYLK QLHPVEWDNF VKDTKILAEE SEGMDGATST
NIEKKTDDLP FYCIGFKTSS PEYTLRTRIW ASLRAQTLYR TVSGMMNYSK AIKLLYRVEN
PDIVQTFGGN TERLERELER MARRKFKFAI SMQRFSKFNK DEQENAEFLL RAYPDLQIAY
LDEEPGPKGG EARLFSTLID GHSEIDEKTG KRKPKFRIEL PGNPILGDGK SDNQNHAIVF
YRGEYLQLID ANQDNYLEEC LKIRNILGEF EEYSCSSQSP YAQWGHKEFS KSPVAIVGTR
EYIFSENIGV LGDIAAGKEQ TFGTMTARAL AWIGGKLHYG HPDFLNATFM TTRGGVSKAQ
KGLHLNEDIF AGMNAFGRGG RIKHSEYYQC GKGRDLGFGT ILNFQTKIGT GMGEQMLSRE
YYYLGTQLPI DRFLTFYYGH PGFHINNILV IYSIQIFMLT LLYLGTLNKQ LAICRVDSSG
NVIGGQPGCY NLVPVFDWIR RCIVSIFLVF FVAFLPLFLQ ELVERGTGKA LLRLGKHFLS
LSPIFEVFST QIYSQSILSN LTFGGARYIA TGRGFATTRI NFSILYSRFA GPSIYMGMRN
LLLLLYATMS LWMPHLIYFW ASVLSLCIAP FVFNPHQFSF ADFIIDYREY LRWMSRGNSR
TKASSWYGYC RLSRTMITGY KKKKLGHPSE KLSGDVPRAT WRSVIFSEVV FPVCVAIVFV
VAYMFVKSFP DANGDLPPSP LIRIAVIAIG PVVWNAAVLM ALFFIALFLG PMMDSWIKFG
SVMAAIAHVL GLVGLVAFFE FFWFLELWDA SHAVLGVICV VAIQRAIQKF LISVVLTREY
KHDETNRAWW TGKWYGRGLG NSAMSQPARE FIVKIVEMSL WTSDFLIGHI LLIILTPPIL
IPYFNRLHST MLFWLRPSKQ IRAPLFSTKQ KRTRRWIVIK YTFVYMVVVS CIAALIVLPA
LFRDRITFEC SICKSI
//
