ID A0A067NZC3_PLEOS Unreviewed; 2697 AA.
AC A0A067NZC3;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN ORFNames=PLEOSDRAFT_1091403 {ECO:0000313|EMBL:KDQ33264.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ33264.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}.
CC -!- SIMILARITY: Belongs to the CLASP family.
CC {ECO:0000256|ARBA:ARBA00009549}.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR EMBL; KL198004; KDQ33264.1; -; Genomic_DNA.
DR STRING; 1137138.A0A067NZC3; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1091403; -.
DR HOGENOM; CLU_000539_0_0_1; -.
DR InParanoid; A0A067NZC3; -.
DR OrthoDB; 5477703at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 3.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..2697
FT /note="TOG domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001647117"
FT DOMAIN 574..808
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 850..1085
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1181..1414
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1445..1680
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1803..2046
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 805..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2036..2170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2479..2550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2627..2697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1698..1714
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2104..2120
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2121..2135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2147..2163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2494..2541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2673..2697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2697 AA; 293268 MW; C4E08E72BBAB85A8 CRC64;
MEHQPTVHIL RPHHITLLAV ILLALKEIDS KNLAPAFSLH IYRVLLNEVI EIVPPKTWSE
LLDVLSAGPS AGEKSGPQLI TVLRGVNSEL SDPTQLSNFF ASKHIFGYFC RRCFVSFLKL
SFEGVIKYHQ DYEAWCNGDR EAGYDIVHKD SLDNCGWLQR VDNLAFSTLF PAYLLLFKSN
VDKKTWADSR SYEIFEAGLA NGDMLTGEEH LRWFFEQRFH EGHDSLLNRL PPVEVGRKPV
LNEIQPTSHP LEVLFDAKKL MDTDNDQNLG ATFAKLAEVL GMLDHYSETQ LIDSEIWAHH
AVQSVAWNAI GCDRLTVIEE DIVTAFTMVG GDDNNRITVI LNRAYRQARQ GQYETALAKL
LEPDIWRGLT IRDYSLWANQ VWHILALRAS QVLLPRQPLG EVDSNDYFFY TCSMKDKIRG
QLYEVLRLRE FGQASTAIEQ LLTALWHAEF QGRMHLYRTG VILLADVGLE FGLTKRCCTI
LDEIMPQVQS MIRLPSIIPD HFQRALACFT LGRCIIAAKG GSELGLQEAL KYLLVAEADC
QTIQLIDPLA DVQYLISVVY HNLGMVAERD EAAMRHTPQE EDFSSIPIGD RITHKNWKAR
VHAYESLIKT FQTTASDTDP AFKPYINNSD LLKKIVTDSN AVAQEKGVEC VVNLVRFAGE
TAAKTRDTVV PALVDKSFGS ARAGTKAQAV ELVLQYVEIE NVGTGVVNDI LPGLGAKQPK
VVATTVVALK EIVRLFGIQV TPPAPILKAL PKIFGHSDKT VRSEGTQLTH ALYQWMGPGI
ETFLGDLKPV QVKELKEAFD AMESEGRGRG TLKAERLTRA QAREKESNID ADIEDEGNQE
EDAAPPDPRD FAEAVDVVPQ LPPSFQAALT SSKWKERKEV LDQMLALLSA TPKIKENSEL
GDLAKSLAVR IQGDANINCV MVAAGCMEAL AKGLMGSFAR YREMVVGPML ERLKERKANV
TDAIGVALDA IFTTTTLSDI IPDLSSALAS KNPQVKEGTL KFLARCLSTA KSPILGPQIK
PMAESLSALL EDSHEGARNE AAVCMGTLMK MVGERPLNAV VDSLADVRKA KVKEAYEKAT
VKCKSGAPAP PKPAASAPAP SSKKAPSKPT AKAAQPNGDT ETEPAKKPAA KPPARLTAKK
PPVASAPAAA AAATKKAPPA ASKSGKAQAS AAAAGSLDTF KYKHTPEDAE SLAADLIPAQ
ITIDLADSNW KTRLAAIEEM TNWLNSVIGD VDAEVVVRAI GKKGWNEKNF QVSASLYGIL
SNLAENCPSF GRSCIALSVP HLVEKLGDMK LKKAAGDTLS VFAEKTSLQF VLNQVYDPLS
KQKAPKVIAD AIAWINTALT DFGIAGLSLR SLIDSLTTAL QNSNAAVRTS ATKTLVTVKL
FAGSSIKDLL EDLNPQLMNT ISGEFDKVEG QPAPEPGKTS ADLANMASSG SQSSGAAVAV
DALDDLFPRI EVDSLLKGTT ILADAKSDAW KTKKEALETL QGLLDQGSNK RLKPTMGEIG
QVLKARVTDT NKAVQTTALD IVARIATGMG KPFEKHCRLF VLPVATVLSD QKAPIRAAAI
QTLAAIATAC EGLEPLVHGI TTALETSNPQ QKGTLLNWLA DWFKEHESTS SVDLNSWALP
VVSCLDDRNS EVRKGAQALL PAIVLHAGFD YVMQQANSLK PASRGSAIPL IQAARPANVP
TPAPPASKSA PKAKATPRGA SPEPPPPPLS PVPAPATKAT KVTGVRRKLP LSSKPASRSE
TPDSTGPRAS GKPAVGGASK AGTKQDESLP FFSSNPEARK ARTAKDSNKW INEGGPTRKD
LAELLQAQME GHASKELLNR LFSHDHNAVN DHILGLSTLC EFFSSQNGDK SLEDICFANF
DLPLKYASIK AHEPQPNLIS KCLEVVETMV AFLRSLNYQL TDSEAMCFIP TFVLKLGDAR
EQVRSRVQAI IQDLPKIYAY SRLFQLLSDY GLKSKVAKTR QGSLDEMAGL LKRFGIGACE
PNKACPIMAS MIADKDSLVR KAALGALGEV YTLVGDKVWS LVGPLPAKDK TQLEERLRRV
PGPPEVAKAE PTLAPPPQIS RIAGGIPRPN SPAGASRFGL PRSASPALVS RSKLARPASP
AAPIRANSPN PRPQSPVRLP ASQPPASTIP QSPTGLARPR SMLPSRLGRP RTNTASTLSP
PVDTIPESIR PTHHVTPSYD DHYDDPNEPP PPAADDITVT ISSILSSDPS RSVDALKKFQ
KILAVSPDAG SSSPQYRELA EHTEGLIETI TLQMTHIFDR PEEFILDENF RLAKHLIQTL
NNFCDHPFLA ESLTVDTLTS LLEELTLRLL ETDDSPVKKV KDLSRFINMI ILRLFATGRR
MSIFRALFAL LLQIVKPFPT NGTSPDSKEA KVAELVLKCI WKLARNIPQD LGEQRLDPVE
LFPAVEHFLQ SVPPNEWRAR ATNKVPCGDM PLRTIKVIIQ HVVAYHGDGV YDLLSGAFDD
PSATIVYPYV YRILNSSNSK AASGDPVTKL TMEPRHHPSQ SPSSSRPLSP QETASNGSAG
HHRSPSHRTS PSVSSANDNG GYPSEEPDPD AQLLTIIGHI SSETTGALHK EGITELHHFL
KAYPHKRPRV EKMLESTGAA FRKYINRALA SRAAEDQERD VAVADTLSKL ESNQRPPVTT
PSSPPPRNGI MPKRTSQPED SGTQEKLSRL HDIFQYRSST LSNGSSQGRG TERTSLS
//
