ID A0A067P0V7_PLEOS Unreviewed; 1279 AA.
AC A0A067P0V7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=PLEOSDRAFT_21793 {ECO:0000313|EMBL:KDQ33958.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ33958.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
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DR EMBL; KL198004; KDQ33958.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067P0V7; -.
DR STRING; 1137138.A0A067P0V7; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_21793; -.
DR HOGENOM; CLU_003290_0_0_1; -.
DR InParanoid; A0A067P0V7; -.
DR OrthoDB; 1422944at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 310..462
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 536..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1279 AA; 139482 MW; E3EE723D6B9FE79A CRC64;
MFSRALQRIR TIGAVFFHHF GLHCATHQIR IILVSCVVIT SLFYPALDLY YSSSSHVPYL
SYLSYVPSLS PFTLRTDSRT TTPLASHVTD LDSIWTPHPS LRTQDDAVSR AQCRLGSSIR
VERILIQGGT ASNENIDSHL NNKILLETFD IEARLGKGLS EQGMNCLKQE RGECLVISPL
LFWDYDLSSL ESEMDIIQAL STSQNVTVSG VLVTPRMILA GRGTLDESTE EDSYDFDFAD
YLVVTYLFPE SDCLGNTEHA SWKDLLSAAT TDLADITFQD AEPELLALQY QPSHEPTAKT
FSIISTFTYL AYAFFFTYVT WSMRRMHRVH SRIGLTFTAL VEITVSTITS LSVCALVGFK
VTMVPWELLP IVIAFLGAEN MFNLVDAVTK TSITLAVKDR IAEGLALAGT SNTLKVVSYN
AILGVIAVFS FGAIRQFCVF AIVVLVAHWF LAHTFFLAVL SIDIQRLGLD ELLKQGTGST
PATVSSSDER KVVIRRTKWQ SLVTHIQNAL RGRARTNLSL FLLLAITAAL YSATYSSSTP
SSVGNAKPRR SQALARNRDA PSQSQTSHSP AHDLWHVLSP NGDQLLHLRI ESPAIMTIKP
FVSDVGPEPG NGPMRTISTD SVRRTRSRLN TKSLFWFLKI VLLPISATTG ALYLLLLYLL
KDAELLEAQR HRDEASSNKT TKEAPKSLDG QISFDTLPRG VEGDIDLVAA TKDGRLIVCV
SVQNEVALWW KPRASTGVGE METDHEDEWL YSTIDTGDLL LRAKATSGFS GSRPQVAIVT
VAVTADASLF ALGTSVGVIG VWEVGWSTDG TTVNTQPLSH LSLSQGTPAV VKTTFVHSAL
SPGRNTPLPS LLVVYSDHQV DEWRLGSSSQ PLPIRPKSDG LLLKSMFTHV YPDDRILVIF
CMDQGRVELA EVGTSYPLLP TSVVLNLGDT SDQIVVAHAS RVELGGSSRL VLGIATSSGS
ISLWDATLGT CISTFDDLYG SINNLKISPV NPERCELCTE VAPESFSVTF SVGQVVQFFR
IYLPGDANHR CSCSRTRSVS AWDNTLLGRR SRSSSVSSLP GSLVGNSGLK SNGGSPLASR
ARLATSYEAA PFPVSGHGIH SRRASEKDRD SSRRLSDILT VPIPFDNFDS QGTGDSVSPC
TTPPAFSWHG ATLVRAFADI MCERGGWDVL DGRIAGIRRR ARLGNVSTNT SLTPSFTGLS
AATLERWEVW VLDPSHSNMR SSPLVALATP IKSPDSPRSP GQAPRLPFTR VSPFISIRSY
GLAGFGNTLG LLDFSSFRC
//