ID A0A067P2V2_PLEOS Unreviewed; 557 AA.
AC A0A067P2V2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN ORFNames=PLEOSDRAFT_1073785 {ECO:0000313|EMBL:KDQ33570.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ33570.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
CC -!- SIMILARITY: Belongs to the anthranilate synthase component I family.
CC {ECO:0000256|ARBA:ARBA00009562}.
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DR EMBL; KL198004; KDQ33570.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067P2V2; -.
DR STRING; 1137138.A0A067P2V2; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1073785; -.
DR HOGENOM; CLU_006493_9_3_1; -.
DR InParanoid; A0A067P2V2; -.
DR OrthoDB; 705at2759; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR005256; Anth_synth_I_PabB.
DR InterPro; IPR015890; Chorismate_C.
DR NCBIfam; TIGR00564; trpE_most; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 37..166
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 226..480
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 557 AA; 61216 MW; 1CE4E9EFE8AE9AE0 CRC64;
MDPSRLPAYP SLAEVEKLII HEKKGNCVPI YVELPADLLT PCMAYMRIAK DSKYSFLLES
VIGGENVARY SFIGADPFKI IKVGPNEEIT GDPMAALQKE LTLYQYVKIP EIPTFTGGAI
GYVSYDCIQH FEPKTTRTLN DPLAIPEAVF MLVDTLLVYD HIFQSLKVVS HVFSPASNGQ
VNLGFVYQTA VSKARRLAKL VVSSATPEIP QPPITLGAEG VSNVGKAGYE QFVTTLKEHI
VAGDIIQAVP SQRLARPTAL HPFNAYRHLR KVNPSPYMFY LDCGDLQIVG ASPETLCKVE
KNVVFNHAIA GTTKRGKTPE EDEKLGAALL ASEKDRAEHI MLVDLARNDV NRVCEPRSVK
VDHLMRLEKF SHVIHLTSQV SGSLREGLTR FDAFRSIFPA GTVSGAPKIK AIEIIYSLEK
ERRGVYAGAV GRFDFASDEM DTCIAIRTMV FKDGVAYLQA GGGIVFDSVE EDEYVETINK
LKGNVRALEE AELDDANGGD VFDCAFANGI HVCEGIEKDN EIGCNFLVFD NVCSVKLHLV
GQSPWKPPFT NVEALSP
//
