ID A0A067P9I9_PLEOS Unreviewed; 662 AA.
AC A0A067P9I9;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN ORFNames=PLEOSDRAFT_1091136 {ECO:0000313|EMBL:KDQ32571.1};
OS Pleurotus ostreatus PC15.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pleurotaceae; Pleurotus.
OX NCBI_TaxID=1137138 {ECO:0000313|EMBL:KDQ32571.1, ECO:0000313|Proteomes:UP000027073};
RN [1] {ECO:0000313|Proteomes:UP000027073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC15 {ECO:0000313|Proteomes:UP000027073};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR EMBL; KL198004; KDQ32571.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067P9I9; -.
DR STRING; 1137138.A0A067P9I9; -.
DR VEuPathDB; FungiDB:PLEOSDRAFT_1091136; -.
DR HOGENOM; CLU_000022_3_6_1; -.
DR InParanoid; A0A067P9I9; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000027073; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361147};
KW Reference proteome {ECO:0000313|Proteomes:UP000027073}.
FT DOMAIN 33..90
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 92..479
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 540..622
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 662 AA; 73210 MW; F6CA733081819FB8 CRC64;
MAEAPEAIPI HPVASRILKG RKKPHVGPHF HAYKQAHEET VGHESDEWWA KTARDTLHWD
RPFRTVRSGG FETGDITWFP EGGLNASYNC VDRWAFKHPN KTAIIYEADE PGEGREVTYS
ELLREVCSVA NVLKSMGVKK GDTVSVYLPM TWHAVAAFLA CARIGAVHSV VFAGFSAESL
RDRAQDCKSR VLITADEGRR GGKTVATKAI VDAALKECPL VEHVLVLRRT GNEVPFTPGR
DKWWHEETLK VPNYCPPEIM ASEDPLFILY TSGSTGKPKG VVHTTGGYLL CAALTVKYVF
DVHPDDKFAC MADIGWITGH TYIVYGPLAN GVSTMVFEST PVYPSPSRYW ETVEKHKLTQ
FYSAPTAIRL LRRLGSHHVE KHDLSSLRVL GSVGEPINPE AWNWYNEHVG KMECAIVDTF
WQTETGSIVV TPFPGAIETK PGAATVPFFG IETAILDPVS GKELEGNNVE GVLALKNPWP
SIARTIYEDH NRYLDTYMKP YPGYFYTGDG AARDEHGYIW IKGRIDDVIN VSGHRLSTAE
IESALILHKG VAETAVIGTP DDLTGQAVYA FVTLKPEFSY DPNDENALVK ELVLQVRKTI
GPFAAPKKIY IVSDLPKTRS GKIMRRIMRK IVAGEGDQLG DLSTVAEPGV VDVIKKKVAE
SA
//
