ID A0A067QFB0_9AGAM Unreviewed; 1351 AA.
AC A0A067QFB0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=JAAARDRAFT_76166 {ECO:0000313|EMBL:KDQ62197.1};
OS Jaapia argillacea MUCL 33604.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Jaapiales; Jaapiaceae; Jaapia.
OX NCBI_TaxID=933084 {ECO:0000313|EMBL:KDQ62197.1, ECO:0000313|Proteomes:UP000027265};
RN [1] {ECO:0000313|Proteomes:UP000027265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUCL 33604 {ECO:0000313|Proteomes:UP000027265};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL197711; KDQ62197.1; -; Genomic_DNA.
DR STRING; 933084.A0A067QFB0; -.
DR HOGENOM; CLU_002632_0_1_1; -.
DR InParanoid; A0A067QFB0; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000027265; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000027265};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 19..78
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 230..264
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 935..1065
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1101..1334
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 127..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1351 AA; 149608 MW; 1DDA20646F60E65A CRC64;
MAAFSSIPSQ ASNEEEQYIA TFFCQALYDY QAQDASSLSF RRNDIIEVIT RLESGWWDGL
LGDERGWFPS NYVTVISDQE AETALSALEN VIPQQVLAED DSVVDMAHSL TRGQSEQDWL
EDDLGFGSPQ TGVEEVPSVT TTAPTQSNDF WEPHLTNDGQ IYYVNTATGQ HSRDLPQEAE
EDHSDSDPTR LPAQSDARSG ASSAVNPPSI RLGRSQEAGS SAGFGLPRRS GTPEPWVRRL
ADDGMSYYYY NKLDGRVQWT LPEAEPRSRG NSLRDRALSQ SNSSLREPVA SSSRLRSDSS
ISQLQGQSQQ RIHTGPDRTS VYSDNSDVDP RERDLSIASS KAKSLNGQVS TNGPQESTYA
RSQEQNDLLE LTSAERLAQT LQQTLAPPPP ESVADLSVKA QDAISSVIEC IQFDGQPRRI
EQDRRMDDRV LAVVLAIRNL LYVASPPSSH ISVNLLPRDA RDYKPNPTAQ SLQAQLKPAQ
RKVTATLSKL VLSARAMQYD SGSSETDTPN RIEADAAELE RAVVAFVLEV ERHHGGVSDF
ENPSKGAKRL HGVLSTANVG LGLVGAGAAG SWKGFGWVAL EQPEDAPTRV LGPEVIAELK
THHLGVIEKV GSLALALQSP DEAAVERLEA DSQEIITQLS SLLVFLADIH VARHVDIDGI
KREASHDDLY MQTVDKARLL VRTLEAAVQS VYDDGFTLFL TSQGLSTGNF FSDGDYIDAL
ATSLKANLGV IQQTLEALLS VGHDQADMAQ GDYNGSIEWR MSRLSVIEHH FGVDLQSMTD
TFLDDSGEGE EDDIVDAELA FGKPRPKMQV SLDPSVMYQN FSQWSEPSLD MSDASHSISN
GDTSSWSMTA QSMDTLVSPS SAGADQEIDM DDVAALDEEE AALVGSSSKS PVRGAKLLKL
LGSDAPQHYI NNANVDAKPW YLRPTYNQTE IIIEPDGSVR AGSVTALVER LTAHELGDPK
FNQTFLMTYK SFTTTGELFE LLVQRFYIHP PEGLSQRELE EWTKLKQAVI RLRVLNIFKS
LLTDEDVFDQ DDNYILDRIK GFLSDDQVMQ ISASKGLMNL VERSLQGGDT MIKMTQSTSG
PTPPPPILPK SMKKLKLIDI DPLELARQLT ILESRLFLKI RPMECLQRSK KSGADHNDSI
SVFITTFNRI ANWVKDTVLN REDSRKRASV VKYFISVADR CRMLHNFSSM AAIVSGLSAS
PLARLKRTWD QVGRGPMQIL ANCHIDTNKN YLVYRSTLAK LTSPCVPFFG IYLSDLVFIG
DGNKDILSGD LVNFRKRQKV AEVIEEIKRW QSRPYNFHPV APVLAFIEDS LSQYADPVDY
DEMFWSVSLE REPREREDEK MARLLQESGF L
//
