ID A0A067QMX0_ZOONE Unreviewed; 1230 AA.
AC A0A067QMX0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=L798_14815 {ECO:0000313|EMBL:KDR10833.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR10833.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR10833.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR10833.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KK853134; KDR10833.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067QMX0; -.
DR STRING; 136037.A0A067QMX0; -.
DR EnsemblMetazoa; KDR10833; KDR10833; L798_14815.
DR eggNOG; KOG1027; Eukaryota.
DR InParanoid; A0A067QMX0; -.
DR OMA; NYWVERF; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 4.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KDR10833.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1230
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001644172"
FT DOMAIN 576..832
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 835..963
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 1028..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1230 AA; 139754 MW; FEE8DCCD15CE3ACE CRC64;
MQHIMRRVFT FLLIVLPFTA SKDASITEGS SKNPVQEWDD PLLLLSTLDG SFYGVGQKTG
YIRWTLKDEP AVKVPVDTTK AIIPLFLPDP KDGSLYVLGS SEREALKKLP FTIPQLVASS
PCRSSDGILY TGKKIDTWFA MDPNTGVKQE ILSFNKADKT CPLDSSDFIF IGRSEYNIIM
FDSKQKERRW NVTFYDYSSN VMDADALNNY EFVHFTASST GRTVSLDRRV GTLLWEENYG
SPVIAIYLLQ NEGLVSVPFT IVAEETLDHL VTQFTSSSDQ IRVSDKMKLY PTLYVGEHLH
GLYALPSLVD QNTVTIGPAQ TGTLLLEGPS QLQSHHEPTL QYHGSSSSSG LPLPGHNVRL
SQSSNHVDIP LTFQSLPKEK NDITEPVILL GYYKVPDYTK TVLQIAGRSD KIITTPESLV
IVDDNETSSE RTAEDLESVK SSVETLVSML QNEEKRTNEK QNLGAQAKEP GGAWEKLASS
NITFYLSKDF ITFSYGTAKL WLNQQENKGL KLTLIVLVGC IFAMFWYYNG QVREYQQLSQ
GSQSSSRSIS GDQSLAISAL AEDVGGGNVQ VGKITFNTSE ILGNGCEGTF VFKGMFDNRA
VAVKRLLPEC FTFADREVDL LRESDEHGNV VRYFCMEQDK QFRYIALELC AATLQDYVEG
KFICTTLSAL EILHQSTAGL EHLHSLDIVH RDIKPHNVLL SMPNAKGEIR AMISDFGLCK
KLKLGRMSFS RRSGVAGTDG WIAPEMLNGF SRTTCAVDIF SLGCVFHYVL SNGNHPFGDA
LRRQGNIISG EFRLSDLQGE EKLLQRILVE QMISSDPMER PPASAVRIHP IFWNKNQVLT
FFQDVSDRVE KDDQESLVLQ ALEQGAHNVV RDDWRNVIDS EVAQDLRKYR NYRGTSVRDL
LRALRNKKHH YRELSQEAQQ SLGEIPNKFI DYWTQRFPLL LLHTWITMQC VKNEPIFSQY
YHKDYIFSQS LYVNGSKDAC SAYSSVTLAD NKLNAVQQWI KMKPEPDTAK RDKTQIPNDI
SEQQYFKQNN FKARKDSEMS PNIRRRNDRG GNRKESSPKR FRNTRRDSYA LKSENWRAED
DPTRHLYQKI DLARARDNVN ITDQPRHLHN TQYSRDSPEN LVLWRDVGRQ TDTRKTLEIT
GTYDTPDFIH RPELKRTDCS DLKPSEIFQT ENSLPVAVDY EKQALPSFRQ QYKQLKNDDR
NQTVKKHHRH KSAEATAVWT LPKSLPPTSD
//
