ID A0A067R124_ZOONE Unreviewed; 1024 AA.
AC A0A067R124;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN ORFNames=L798_14399 {ECO:0000313|EMBL:KDR11229.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR11229.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR11229.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR11229.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR EMBL; KK853110; KDR11229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067R124; -.
DR STRING; 136037.A0A067R124; -.
DR EnsemblMetazoa; KDR11229; KDR11229; L798_14399.
DR eggNOG; KOG1959; Eukaryota.
DR InParanoid; A0A067R124; -.
DR OMA; WIYQINR; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 24..1024
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5017850837"
FT DOMAIN 384..459
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1024 AA; 117139 MW; A183C03C78A2D594 CRC64;
MGWLCQTLIF MAVWCFVVHN GFTTPVTDNI LITTPPTAKP PSKHEDSNCG YESCTKAKPG
KLNVHLVPHT HNDVGWLKTV DQYYYGSKSS IQKAGVQYII DSVLTELHHD PEKRFIYVET
AFWWKWWMNQ HDTIRHQVKK LVNNGQLEFI SGGWSMNDEA VTNYQSIIDQ LTWGFRKLND
TFGKCGQPHI GWQIDPFGHS REMASIFARM GFDGLFLGRL DYQDKMARFL TKTAEMVWQG
SENLGKAAQL FTSVLYNNYA PPPGFCFDVL CDDEPFIDDK HSPDYNVDTL VSRFVDYVET
QAIFYSTNNI LLTMGGDFTY QEAHMWYKNL DKLIRYVNAQ QSNNSTVNVF YSTPSCYVKA
VHDVGQTWTT KQDDFFPYAS DPHTYWTGFY TSRPTLKRFE RVGNNFLQIC KQLYSLTDLG
PEDSVDLNKM REAMGIMQHH DAVTGTERQK VASDYARVLF EGFEECGIIA QAAINKLIAN
KKQSEVSRVD AVPIKSCLLL NISQCDILDY SNQFVVTVYN PLSHRVSHYV RVPVSGASYT
VQDPTGKQLK IQLVPIPQPV IEIPGRVSPA TMELVFYAKD LPPLGFRSYY ISGSNHIHHT
SKYKIHPGRD VILGNTKFNA VLDWETGSLK SMVLDRTKFS VSQDFYYYKG YIGDNKEFVN
RSSGAYIFRP NGSEALSVSS TKKSSTYKGD LVDETHIKWS DWLSQVVRYY KEDTYHVEME
WLAGPIPVDD NVGKEIISRF KSDLLSDGLF YTDSNGREML ERKRNFRPTW SVNIKEPVSA
NYYPVTSRIT LRDGDKEFSI LTDRAQGGTS LNNGEVELMV HRRLLHDDAF GVSEALNETA
FGHGLVAIGK HWLTGGNISS GTAAQRTRSL QQQVLLSPWL FFTPADNISF TEWVSHYKME
FSGLNQELPE NVHILTLEPW KAHSFLLRLE HIYERNEHPV FSKPATVNLK NLFKPFSIVM
ARETTLGGNQ WLSESHRFKW QSENDINFTL EDDEDSSKED KDALTITLGP MQIRTFIIEV
NFLQ
//
