ID   A0A067RFD0_ZOONE        Unreviewed;       756 AA.
AC   A0A067RFD0;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Hormone-sensitive lipase {ECO:0000313|EMBL:KDR22472.1};
GN   ORFNames=L798_02269 {ECO:0000313|EMBL:KDR22472.1};
OS   Zootermopsis nevadensis (Dampwood termite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC   Termopsidae; Zootermopsis.
OX   NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR22472.1, ECO:0000313|Proteomes:UP000027135};
RN   [1] {ECO:0000313|EMBL:KDR22472.1, ECO:0000313|Proteomes:UP000027135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Whole organism {ECO:0000313|EMBL:KDR22472.1};
RX   PubMed=24845553; DOI=10.1038/ncomms4636;
RA   Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA   Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA   Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA   Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA   Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA   Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA   Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA   Liebig J.;
RT   "Molecular traces of alternative social organization in a termite genome.";
RL   Nat. Commun. 5:3636-3636(2014).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KK852506; KDR22472.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A067RFD0; -.
DR   STRING; 136037.A0A067RFD0; -.
DR   EnsemblMetazoa; KDR22472; KDR22472; L798_02269.
DR   eggNOG; KOG4388; Eukaryota.
DR   InParanoid; A0A067RFD0; -.
DR   OMA; NACITHG; -.
DR   Proteomes; UP000027135; Unassembled WGS sequence.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   InterPro; IPR010468; HSL_N.
DR   PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR   PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR   Pfam; PF07859; Abhydrolase_3; 2.
DR   Pfam; PF06350; HSL_N; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027135}.
FT   DOMAIN          24..326
FT                   /note="Hormone-sensitive lipase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06350"
FT   DOMAIN          345..494
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   DOMAIN          668..730
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   REGION          491..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..506
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  83058 MW;  D43CDC79B23FAF6F CRC64;
     MTDSEEYASC ASVEASSSPF YAMYRVLKDL CTNNAQFFQQ DESESGQRLN AGFLALIDQV
     DMIIPMVDDV RKIAPLYDFD EGTPGNGYRS FVSVIDKCVQ HGVKLSRLVC DSRDSFLFRK
     TFYMREVEAC SHLLASLGTC MAHLQTLLSW STESQLFPDE QHSTEDLLNR VESINMYCFY
     GRCLGFQFCE SMQKILKTVS ICMASFSEIY YGNGGLLARA TSSVWTGGKY LLDPELRARR
     IVNISKHASV DFCKSFWHLA DTELMGRLPG MVCPAVAVNK VVCIPPEPLV HIAPDGCAIS
     VPIPTAHFGP APIMARFLSA VRREGMIADS KERGSNLLPP SPGLIIHCHG GGFVAQSSRS
     HEIYLRDWAC QLKVPMLSID YSLAPQAPFP RALEEALYAY CWAINNAHIM GSTAEKVILV
     GDSAGANLNI GVTMKCIELG IRVPNGLFLA YVPVLVSFVP SPSRLLCLMD PLLPFGFMIR
     CMKAYACPSK DDITSTSSNT KTLLEGSDTE SFEEVSESDL QELAAHKSVL SNDSDTLTTV
     SLASLQSKAE ADHTVENNGA PNPAECYMEK YVLDSDTDSE GCKIQVLRSK PKVEENVLFE
     VPTQQDSGLS SRLGRAVGNI ANYMTGTEPQ QTPAGKQGQS LSLGSESLEA LDSLMQRSAS
     DDLHFTIPRD PYLSPYWASD EVLKQLPTTK IVSVQLDPCL DDCVMFAKKL KKLGVAVSLD
     VMEGLPHGFL NFSQLSKEAR SGSNQCVRRI QELLCL
//