ID A0A067RGY6_ZOONE Unreviewed; 711 AA.
AC A0A067RGY6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 16 {ECO:0000313|EMBL:KDR22288.1};
GN ORFNames=L798_02395 {ECO:0000313|EMBL:KDR22288.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR22288.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR22288.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR22288.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK852513; KDR22288.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067RGY6; -.
DR STRING; 136037.A0A067RGY6; -.
DR MEROPS; M12.A51; -.
DR EnsemblMetazoa; KDR22288; KDR22288; L798_02395.
DR eggNOG; KOG3538; Eukaryota.
DR InParanoid; A0A067RGY6; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04272; ZnMc_salivary_gland_MPs; 1.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR034030; ZnMc_salivary_gland_MPs.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF243; SOL NARAE, ISOFORM C; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF13582; Reprolysin_3; 1.
DR SMART; SM00608; ACR; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Integrin {ECO:0000313|EMBL:KDR22288.1};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT DOMAIN 83..315
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT REGION 400..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 245
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 244
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 248
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 254
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 711 AA; 80155 MW; B0E61F90A23362F3 CRC64;
MFLDENGEDI QEDVAIETGF PLRRIQSTSN SEPKPQQHII YRRSSSQFEE PEFSDYAFME
PDHLAKKFRS KRSISKREAP YVIYPEILVI VDYDGYRLHG GDNVQIKRYF VSFWNGVDLR
YKLLKGPKIR ISIAGIIISR GRDATPYLER NRVGRDAIDS AAALTDMGKY LFRERRLPVY
DIAVAVTKLD MCRRQYANDV CNRGTAGFAY VGGACVVNKR LEKVNSVAII EDTGGFSGII
VGAHEVGHLL GAVHDGSPPP SYLGGPGAEK CRWEDGYIMS DLRHTEKGFR WSSCSISSFH
HFLNGDTATC LYNSPHEDES LPRVLPGKLL TLDAQCRKDR GTSACFKDDR VCAQLFCFDA
GSGYCVAYRP AAEGSPCGDG QYCLNGRCVA EHENIIPDYS QNTPSYLRRN DADSAATQTR
PIYTHPPNGT SQRSPLDEYW SKGSTTTPTP SPNPNKYINN YYNKDNSYFD STYNTTKNPH
TFNQHYTQST SYFYSSTTKN PYSFNNNQYS TTKNPLSFNI FASYSTTRNL YDFSNNKYTT
TKNPYDFGNL NHYTTKSNAN SQTPEPVKIF HNYNQYYSSS TTKNPFVGFN YYSTTAKPEH
TSNSVYKLLN NNYNAFTTPS TTTTNKILPN YISSASQNSP SIINMNIEAS VSNVGDIDGC
IDRIANIRGS MTCREFLTHY GFQYCSYKYM QRNCCASQRA VCASAATHQQ D
//
