ID A0A067RHH7_ZOONE Unreviewed; 1626 AA.
AC A0A067RHH7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=GTPase-activating protein and VPS9 domain-containing protein 1 {ECO:0000313|EMBL:KDR23316.1};
GN ORFNames=L798_05277 {ECO:0000313|EMBL:KDR23316.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR23316.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR23316.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR23316.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
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DR EMBL; KK852463; KDR23316.1; -; Genomic_DNA.
DR STRING; 136037.A0A067RHH7; -.
DR EnsemblMetazoa; KDR23316; KDR23316; L798_05277.
DR eggNOG; KOG2319; Eukaryota.
DR InParanoid; A0A067RHH7; -.
DR OMA; ENHEIML; -.
DR OrthoDB; 20678at2759; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd05129; RasGAP_RAP6; 1.
DR Gene3D; 1.10.246.120; -; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135}.
FT DOMAIN 157..361
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1486..1626
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 497..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1626 AA; 178671 MW; A58435295820B709 CRC64;
MDDGLMMNAL HWDIIELAGH LRQERLFVSS EQQHLQGLNE KVISGSCRLA QLAWVTAQQR
DNLNRLIVAH PDCTPAVCCR KANTLDSTVF VDGYKVLGFQ ECLAYGEFLQ TLRTSPQLLA
SCLVAGDRLL PDMMHGIVHS IMTGLFGSSL LPEDKLLALR LLRYLTELQL VPSENPRRLL
RQRSCAFARL YGEFHEGLFS AKLFLTAALH KPIMQLLVED EMFLDIDPDK ATIRFPPEER
LKKFGPEGSP EYNIRLQEYR RWTNKRLVAI TNRFVLSLRN NMHCFPTGVR WLVCQIAGLL
SKSGNIEPKE VNAICTDLVF TYFICPAIVN PEPYGITDAP ISYVSCFNLI QVAKIVQMLA
MTKYEDVDSK VSDLYNLFEK DCVSSLLDAI LDGATDGLED GPVITVCSKL QGLSRSAALF
TETELHQLVV FLQTVSTDED ESLEENRKQL TTLLMQLPFG NTTVNGHVTG GVLKPQQPAT
PSTPRKSAGL LGIVGKGRVA RTSSSPASST TVEGTEESIG GEEDNGERGS QDVLVIPFTP
NVGESVGLIA EQKILCMEEH SSCAEARVRV NLPDSQEERS GGEGGNVGER VESQEKRTRF
SLSHDEGSIG NASDNLEAVS EAASNHSVAS SLELENDQND NLSDMVSANV SGRGTPNISG
RDTPSSQITE GEEGPGGVLR GPAGEPRQPL DFPPPPPNKQ SRSDIDDKFG KFEIKKLLEG
DETVSMVSDT WSTDVLASDS ETVEQSSERN FPTNTTDGAV NQLAETQLLD VSETASEAWS
TDVLASDSER LTEVDTDDTG SVARSDDTAR SEVEVEGRGE PEGGEDATTS TAPLGVNLGF
RPIREDPVGR ASFLAPSSPT RVEGGSHPAW NVTGRGGGKA DYRRRTVEYV ANNPAHRSHV
PIDFNKHGCQ STTEETRLIH VIDKIDKPLD LKPAVVAASQ ASVSIVHIPG SVTLPVLHNG
HNASTAHLPQ NGELDPSHPP PLLSSHVATN TVPMVHIQAN HASAQSIGVT SHIHPHLPST
AHHVGDGSTA NADADQKPEI HGEEEADRDS VGDIIPSVVR LSSTSLASTS SSGSGSDPRP
KTVTPTPDLP LTPTTLVLNG HAMMADGEVT VTKPQSAGSS TGAIPKSISF DKTAERGDKD
LLDDDQKHKR GFFRNFKLSF KSRRVKSLRG SDDFGNRCYE ASLTASDGDV SHLRLRRGMS
EDVRSTHNCN DTTEDILAKY RRKPSAGGDS TVSEPGTELK APQLVGEVED ERLRMDPTNI
ESSYAFIDAK RKLRMVLSTA DLQHVPWATD ASTHMRESRV QKENELVSFL RLQLAEAINL
QDRSLIAHLH ETLRCIQLFD DSGCQKLFKS LKEDYQKRSP YIAYLVRCRQ GLLSTLAHLE
RLTERLKCDR QVCSRFLVAV CVTMFLEKRE EILGSFTVEF QQLTLADEKT DLLDNFLHTL
SLEMDKDPTW QAASSTQLEQ ARTAVERAVI SRVYTHALYP NGDGDVSRDQ VLYEHMKKLS
NVITPNHKDL RIPKVFHYEC PWPSAQAEIS AMAAYKTPCD KLQCVFRCAT TIMNLLSMAS
GRGVPAADDF VPVLVYVLIK ANPPSLLSTV QYVNSFYGNR LKGEEQYWWI QFCSAIEFIK
TMDYSD
//
