ID A0A067RNC2_ZOONE Unreviewed; 527 AA.
AC A0A067RNC2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
DE Flags: Fragment;
GN ORFNames=L798_03611 {ECO:0000313|EMBL:KDR21204.1};
OS Zootermopsis nevadensis (Dampwood termite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae;
OC Termopsidae; Zootermopsis.
OX NCBI_TaxID=136037 {ECO:0000313|EMBL:KDR21204.1, ECO:0000313|Proteomes:UP000027135};
RN [1] {ECO:0000313|EMBL:KDR21204.1, ECO:0000313|Proteomes:UP000027135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Whole organism {ECO:0000313|EMBL:KDR21204.1};
RX PubMed=24845553; DOI=10.1038/ncomms4636;
RA Terrapon N., Li C., Robertson H.M., Ji L., Meng X., Booth W., Chen Z.,
RA Childers C.P., Glastad K.M., Gokhale K., Gowin J., Gronenberg W.,
RA Hermansen R.A., Hu H., Hunt B.G., Huylmans A.K., Khalil S.M.,
RA Mitchell R.D., Munoz-Torres M.C., Mustard J.A., Pan H., Reese J.T.,
RA Scharf M.E., Sun F., Vogel H., Xiao J., Yang W., Yang Z., Yang Z., Zhou J.,
RA Zhu J., Brent C.S., Elsik C.G., Goodisman M.A., Liberles D.A., Roe R.M.,
RA Vargo E.L., Vilcinskas A., Wang J., Bornberg-Bauer E., Korb J., Zhang G.,
RA Liebig J.;
RT "Molecular traces of alternative social organization in a termite genome.";
RL Nat. Commun. 5:3636-3636(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; KK852567; KDR21204.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067RNC2; -.
DR STRING; 136037.A0A067RNC2; -.
DR EnsemblMetazoa; KDR21204; KDR21204; L798_03611.
DR eggNOG; KOG2499; Eukaryota.
DR InParanoid; A0A067RNC2; -.
DR OMA; STSYYNW; -.
DR Proteomes; UP000027135; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF42; BETA-N-ACETYLHEXOSAMINIDASE; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000027135}.
FT DOMAIN 81..138
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 175..484
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 340
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KDR21204.1"
SQ SEQUENCE 527 AA; 59185 MW; C8E0C37A88CCA726 CRC64;
SQSACRLTCG QYGALWPRPT GPTTIGEQVV AFHPSAIRIH LLEVVDSNRG PREYMAACTQ
LFLDNLLVEC GTNCSVVPDT DVHIHLVTRS EDLSLSWNTD ETYTLDIVSN SRVNGVTVNI
RAETVYGARH GLETLSQLVA RVPAPTGATG RSRGAPRKHL LIMATNVRLS DAPVFRHRGL
MLDTARNFLP LYAMKRTLDA MAASKLNVLH WHATDSQSFP LESHRVPQLS RFGAYSARQV
YTPQDVAYLL EYARLRGVRI IMELDAPSHA GNGWQWGEAA GLGKLAVCVN QQPWRKYCIQ
PPCGQLNPTN PNLYRVLRDL YRDILDIFPL GESLHMGGDE VHFPCWNSSA EIVDWMEARG
LGRTQADFLQ LWAHLTETGV IESFLNKDRY IIQTWVPASS SLPAELLAKG YRVIYSTKDA
WYLDHGFWGS TVYHNWKVVY DNKIPRKAGV LGGEACMWSE LVDNQSLDAK VWPRTAAMAE
RLWADPDSRS SSAEARFYRH RLRLVTRGIK AETVAPAYCY QNEGECQ
//
