ID A0A067SR86_GALM3 Unreviewed; 730 AA.
AC A0A067SR86;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=GALMADRAFT_252658 {ECO:0000313|EMBL:KDR72527.1};
OS Galerina marginata (strain CBS 339.88).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Galerina.
OX NCBI_TaxID=685588 {ECO:0000313|EMBL:KDR72527.1, ECO:0000313|Proteomes:UP000027222};
RN [1] {ECO:0000313|Proteomes:UP000027222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 339.88 {ECO:0000313|Proteomes:UP000027222};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KL142388; KDR72527.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067SR86; -.
DR STRING; 685588.A0A067SR86; -.
DR HOGENOM; CLU_004131_2_0_1; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000027222; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000027222}.
FT DOMAIN 227..368
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 243..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 82534 MW; 711B403D0841A1C0 CRC64;
MEDNIAVEPK PIRRLNETLI NKIAAGEIIH RPASALKELL ENSLDASATS IRVTVKEGGM
KLLQIQDNGC GIRKTDLPIL AERFTTSKLS TFSDLSRITT YGFRGEALAS MSHVAHLSVV
TKTKADSCAW KATYSDGALV DPKTGQKCDP RPCAGNDGTM ITIDDLFYNT PTRLSALRST
SEEYSRILDV VTKYAIHNPS VSFVCKKAGA PTPDLSTPSA SDTPTAIRLL YGHSIAKELL
HHKLSSAGKK RQEDDMNEDE DDDENDNDNA ESWIAETYFT NANYQAKKMV FLLFINHRLV
ESSRMKRAFE SAYQSILPKG SSPFVYLSLQ INPRSVDVNV HPTKREVHFL NEEAITEKIA
DGIQETLAKQ SHSRTFEYQT LLTGGIMGDE KTLSKKRSRQ ERDLSEDEQE PEEPGEPSSS
TADPKRKVYS QHKVRTCLQD RTLDSMFPVV NQTQTQADAS SSKLSETPPT TTLGKLREVK
ESRCFLTSVK NLRQSILKGK HRQLTEILEK HTFIGIVDIH RCLSLIQSST KLYLVNHDAL
AEELFYQLGL RQFGDFSRIK LEPSPSLREM IEIAVETEDI ESTRLTKVEI VARVEKILME
RREMLAEYFS LSISEAGFVE SIPLLLRDYV PNLDNLPGFL MRLGPQIDWT SEAECFETFL
RELAYFYTPT PPFPEPGVDE KDQYKAERWQ IQHILFPAMR RHLVAPKSLL DRDVVQIANL
PDLYKVFERC
//
