ID A0A067T8I7_GALM3 Unreviewed; 965 AA.
AC A0A067T8I7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=GALMADRAFT_17346 {ECO:0000313|EMBL:KDR76234.1};
OS Galerina marginata (strain CBS 339.88).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Galerina.
OX NCBI_TaxID=685588 {ECO:0000313|EMBL:KDR76234.1, ECO:0000313|Proteomes:UP000027222};
RN [1] {ECO:0000313|Proteomes:UP000027222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 339.88 {ECO:0000313|Proteomes:UP000027222};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
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DR EMBL; KL142379; KDR76234.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067T8I7; -.
DR STRING; 685588.A0A067T8I7; -.
DR HOGENOM; CLU_005275_0_0_1; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000027222; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000027222}.
FT DOMAIN 195..388
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 423..553
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 591..913
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KDR76234.1"
FT NON_TER 965
FT /evidence="ECO:0000313|EMBL:KDR76234.1"
SQ SEQUENCE 965 AA; 107959 MW; D56E1F3312939E67 CRC64;
PGYSFEVTPP ANQEPLHNPW DFQPAVQSQP PSNFVRPRVR SMQEHSPRLS GDSGYGEFGV
PTMAFPEPTI YRSTSHRQNL QPSQRSAHYY SKSDLAGPNS FANGDSRRSH HPNPSVASFA
SSYNGAYDDV PYGSGSQESY DDDSGELVRG LSDASLASEE GLRRFQAGEL PENDQEWHRL
VPTEAREALG KQEVQRQSVI FEVIKSEREY VADLEAVQEV FVERLRMADP PILKEPHLSA
FINEVFGNLR EIVSYHQAIL AALFARQRDQ HPLIQSVADI VLDTTLKSHF RSAYETYIKH
YPLAESHHRK QLKRNHAYEV FVHSASNDPR IRKRDLITFL SRPVTKLPRL NLLLEQILKL
TDPEHPDLEI LPIILGILRD CIKSTQPGIE AAESKVKFWG LCESLVFQKG EIIDMDLYDE
SRSLVYTGPV FRRSRTETGF SEKWSELVAA LLDNYFILTR EEKRPNGTTK RLLMSRPMPL
SFLRLGSFDA PPEFRREKVD DGRLLDSFRT QSIPVYPFTV YHAASRSTRR YTLYVASDAL
RKKWYNAFVD AIGVHKVRQE SNLWFNPQNL SDGFFRTAGK DTQPSAGSKM TGKIQCAVPF
GDGTRRFLAV GCGSGIYAAP VNTENYRLVL PCKNPTSLSA LTTWRDKSFN RLVVHVDGSI
LSYSLDILAR LAAGQTHPQT LEASLERIGG SDANIVFCRF LLVGGRALLI YSSKRRLGSS
LTVQVLEAIS SSELSLAPRR PSTASTTSAM RTFRPYGEPG YIPKDAHDIV ALVKTIGICT
SGGIVTADPT NLANSVVALV PDLQHAGNNN EPMASLKTRL EGLKPLGLVR VDANELLVIY
DEIGCYIDKR GVPTRRCGYI KWEVKAVSYA SRNGHILLIS PEFIEIRSIT TGRIVQVIDG
HDIRLLYSGP YVAKEDPVLV AMRGGKSDKD GVSDKIVELI QTEEITSLMS PTATVQSSIW
DEWDM
//
