ID A0A067T9L6_GALM3 Unreviewed; 2164 AA.
AC A0A067T9L6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Sec63-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GALMADRAFT_139507 {ECO:0000313|EMBL:KDR76589.1};
OS Galerina marginata (strain CBS 339.88).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Galerina.
OX NCBI_TaxID=685588 {ECO:0000313|EMBL:KDR76589.1, ECO:0000313|Proteomes:UP000027222};
RN [1] {ECO:0000313|Proteomes:UP000027222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 339.88 {ECO:0000313|Proteomes:UP000027222};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
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DR EMBL; KL142378; KDR76589.1; -; Genomic_DNA.
DR STRING; 685588.A0A067T9L6; -.
DR HOGENOM; CLU_000335_1_0_1; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000027222; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027222}.
FT DOMAIN 504..688
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 723..917
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1353..1529
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 25..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..260
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2164 AA; 244519 MW; D6FC57F096F9AFB2 CRC64;
MSGRGKPDLS GYNYGAISSL VLTTDRSALP RRDKEPDGAP VSLAGRIDPK DMGSRVIRQA
PKDLDKKKKK AVEGADPSEK AAVKRKAEAA GFGYADIIEA TQDVEGLTYR PRTAETRQVY
ELILSAVHTS LGDQAQDIVR SAADAVLETL KNENMKDFDK KKEVEEVVGL ISGEQFSQLV
SLSKKITDYN ADDETMADPD QERKDAEIDE EGGVAVVFDE EEQEEEDEEG FEIREDSDED
EDEGEKEDEN DVEAEGNDED IVIGGESSGK NKVKAEKDIV SPHSIDGFWV QRQISEVYPD
PVTAADKAAS VLSILGSESS ARDAENQLME LFEYQSFHIT AKFLKNREVV VWCTKLMRSD
AEERVNVEVA MREKGLGWIL RDLAGDRQTK ASRSDAMDVD ESKPAQVPKT ATLAPGSTVQ
PKRTVDLESM AFSQGGHLMS NKKCKLPDGS FKRAKKGYEE IHVPAPKQKA VAEGELVPIS
SLPEWARQAF TVPKLNRVQS KLYPIAFGTD EPILLCAPTG AGKTNVALLT ILNEMSKHRN
AETGEFDLDA FKIVYIAPMK ALVQEMVGNF TQRLKVFGIK VGELTGDSQM TKQQIAETQI
IVTTPEKWDV ITRKQTDTSY TNLVRLVIID EIHLLHDDRG PVLESVVART IRRMEQTHEY
VRLVGLSATL PNYQDVATFL RVDEKKGLFY FDASYRPCGL QQQFIGVSEK KAIKRYQITN
EVCYEKVLDQ VSNKNQVLVF VHSRKETAKT AKFLKDMAIE KETITQFVRP DAASREILQE
EAGSAKDRNL KELLPFGFAI HHAGMSREDR VVVEELFADN QVQVLVCTAT LAWGVNLPAH
AVIIKGTQIY NPEKGKWVEL SSQDVLQMLG RAGRPQYDTY GEGVIITNHS ELQYYLSLLN
QQLPIESQFV AKLADNLNAE IVLGTVRNRD EAVQWMGYTY LYVRMLRSPA LYGVGADYQD
DDTGLIQKRA DIAHSAAVLL EKCQLIKYER SSGRFTSTEL GKIASHYYVT YNSMMVYNQH
LRPTMSALEL FRVFALSNEF RLLPVRQEEK LELAKLLERV PIPVKETVEE PAAKINVLLQ
AYISQLKLDG FVLVADMVFV QQSAGRILRA MFEICLKRGW AVPAKAALDM CKMVDKRMWG
AMTPLRQFKG VPPEVVRKAE GKQFPWYRYF DLTPPEIGEL IGVPNAGRLV HRLVHNFPKL
QLQAQVQPIT RSLLHIDLSI VPDFRWDEKI HGSAETFLII VEDVDGEVIL FHDTFVLRQR
YAEDEHTVTL TVPMFEPVPP NYYISVISDR WLHAETRLPI SFKHLILPKK FPKPTPLLDL
QALPLSALHN EEFEALYANT IQTFNKIQTQ VFQALYTSDE NVFIGAPTGS GKTICAEFAL
LRLWSKRERS RAVCIEPYQE MVDLRVKEWK KKFQNLQDGK QIVSLTGETS SDLRMLEVGD
VIVCTPTQWD MISRRWRQRK AVQTLGLLIA DEVQMVGGEV GPVYEVVISR TRYVERQTGN
KTRIVACGVS LANAEDLGKW MGASEHTIFN FSPSARPLDM SIHIQSFSIP HFPSLMIAMS
KPTYLAIKEY SPSKPVIVFV PSRRQCRLTV DDLLTHCSAD DQPDMFLNIE LEDLQPHLDH
INDKALVETL KHGIGYYHEA LDKRDKIIVQ RLFESGAIQV LVASKDTAWS LPVASYMVII
MGVQFYEGKE HRYVDYPVMD VLQMMGKACR PLEDENSRCV LMCQQTRKDF YKKFISEGLP
IESHLPTHYL HDYFLAEIAV KTIENKQDAM DVLTWTYFYK RMLENPNYYN LHNTSHQHVS
DHLSELVETT LNDLVNSKCI SIEDEMDVAP LNLGMIAAYY NISYVTVEVY TLSLKERTKL
KGLLEVVSSS AEFESIPIRR HEDTLLRRIY DRVPVKLDRA DFEAPHFKTF LLLQAHFSRI
QLPPDLAADQ TLVLEKVLNL LSACVDVMSS NAWLNALGAM DLSQMCVQAM WETDSPLKQI
PHFEPDVIKR CKGANIESVY DVMEMEDDQR NELLQMSPAQ MRDVATFVNS YPTLDVSHEL
VKGEYTAGSS IFLKVTLARD IDEDDQSDQT VVAPFYPLKK LANWWLVVGD PATRQLLVIK
RVTVTKSLAA KLEFSLPKGK HSLKLYVICD SYVGADHDIA LDPIDVAEGE DSDSDEDMDS
DENE
//
