ID   A0A067TE73_GALM3        Unreviewed;       767 AA.
AC   A0A067TE73;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=ELMO domain-containing protein {ECO:0000259|PROSITE:PS51335};
GN   ORFNames=GALMADRAFT_222250 {ECO:0000313|EMBL:KDR80657.1};
OS   Galerina marginata (strain CBS 339.88).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Galerina.
OX   NCBI_TaxID=685588 {ECO:0000313|EMBL:KDR80657.1, ECO:0000313|Proteomes:UP000027222};
RN   [1] {ECO:0000313|Proteomes:UP000027222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 339.88 {ECO:0000313|Proteomes:UP000027222};
RX   PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA   Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA   Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA   LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA   Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA   Hibbett D.S., Grigoriev I.V.;
RT   "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT   white-rot/brown-rot paradigm for wood decay fungi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
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DR   EMBL; KL142371; KDR80657.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A067TE73; -.
DR   STRING; 685588.A0A067TE73; -.
DR   HOGENOM; CLU_009191_1_0_1; -.
DR   OrthoDB; 1473500at2759; -.
DR   Proteomes; UP000027222; Unassembled WGS sequence.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771:SF56; CED-12; 1.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027222};
KW   SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT   DOMAIN          357..512
FT                   /note="ELMO"
FT                   /evidence="ECO:0000259|PROSITE:PS51335"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   767 AA;  86199 MW;  122E59320257B24C CRC64;
     MSNSGHASSA VRSPLGPSNS ANGTQAKPGA LVPTNNVTTG DGLTVRTRID PTLTVDDVMK
     QLCLNLKIKE PPSHFALRDD TDELVTNDNL RKKIRNKVNL KLVNAPAREA RETAEKLRNR
     NDKNIKLTLF SLQKFIREEA FAHEFLDHNG LNELVDVIYT ATGNTLAYAL AAMQNLMELE
     YGWATLSDDF ILKVVQILSS PQSLINVCRP ATAILKKLVE ADPTSIPGPQ IASSSRGPPA
     PPPGSIYRYG FHIVFEQMRK ERGLLETVVN RLGSADTAMA QYSMMLINSL LAHASDARWE
     EFISELERLN VRKAVVRLMS LHTIEDLTSC ILDFQANVIR VTYRKKTTIV DPDVDESHAD
     ALKSIWACSR LDEELDPSGQ KLKWRKLGFE TEDIVQEFSE VGVLGLECLK KFVESDPDFS
     KVILEQLSRP EERRCPIAKA SNEVVELLSE HWAIFAPGYS TSTTFQRFFL DFPKVHSLAT
     QFFIRMWSES GAATGDFTRV AALVRSQVKV ALRRENVRPW HEVEHDFIEC EYRAVRDRQM
     KELELEDDLL SKVPVRNLRA KLYKESFEFV RQQRIQCLLQ GAWFVNALSQ SSPREVLRRP
     SRPWRFMRLD SGLKFLHYVD SAIKFPVRNG LEDLPERIDM SLISEIATGT CAPPPNVLRD
     QNDLPPTSAL MPSPLSFSLL SAHEGSLADL IAPDQSRWAD WTDGLNMLRR DGGHVASKET
     AGFVQALTEI GLKIKLLDLS GEMVEIPSGL VAGPPPMNND FFFSELM
//