ID A0A067TJR5_GALM3 Unreviewed; 588 AA.
AC A0A067TJR5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
GN ORFNames=GALMADRAFT_235496 {ECO:0000313|EMBL:KDR83391.1};
OS Galerina marginata (strain CBS 339.88).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Galerina.
OX NCBI_TaxID=685588 {ECO:0000313|EMBL:KDR83391.1, ECO:0000313|Proteomes:UP000027222};
RN [1] {ECO:0000313|Proteomes:UP000027222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 339.88 {ECO:0000313|Proteomes:UP000027222};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC Evidence={ECO:0000256|ARBA:ARBA00036277};
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL142368; KDR83391.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067TJR5; -.
DR STRING; 685588.A0A067TJR5; -.
DR HOGENOM; CLU_018702_1_1_1; -.
DR OrthoDB; 179166at2759; -.
DR Proteomes; UP000027222; Unassembled WGS sequence.
DR GO; GO:0001734; F:mRNA (N6-adenosine)-methyltransferase activity; IEA:UniProt.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000027222};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 282..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 65557 MW; 85D3C4FA1194C450 CRC64;
MLDDELKIVA VTAFNTLIAS RKVNTPITSM DLLTSVITTK MPSGLLPKSP TPKFRLTDLT
RFEGIVEDLS NTWTDGIIIF SRDEVTGNMM IWDLGLRVPG SVSRPLLGVG LPSSNSAGGD
LSGLVSRKRK RVVDEDADSA AGDEEEFLEE EDFAAASRST LANLNAEMRE VYTILQKSTT
KGRLLAEQFH TRGGNFNPIC SHITKDDCAK ARRASSTDQL HNAAYGSNQP PAPTSICDRV
HFRPLIRPHT DVTLGHCSYL NTCYSEPTYA QSPSIPPFPG STHAHGMAPP GMRGPVSLPS
GLGAGGRGKE KAPCRYLHYE IDWDGGDGEW MSERKPRKKM HRLRIGLGPS GKVTKPLPPQ
WINCDLRTFD YSTLGKFHVI MADPPWDIHM SLPYGTMNDD EMRKMPIPIL QDEGFLFLWV
TGRAMEVGRE CMRVWGYTRI DEVVWVKTNQ LQRVIRTGRT GHWLNHTKEH MLVGVKTVLD
ANGALKFPSW ANRALDTDVI VSEVRETSRK PEEVYGLIER LCPGGRKVEI FGRKHNARPG
WLTLGNQLGP DQIFEEDLAL RIKAKYPDRP IKMPTPYKNP RAGLPKVL
//
