ID A0A067TKS0_GALM3 Unreviewed; 1845 AA.
AC A0A067TKS0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GALMADRAFT_236120 {ECO:0000313|EMBL:KDR83761.1};
OS Galerina marginata (strain CBS 339.88).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Galerina.
OX NCBI_TaxID=685588 {ECO:0000313|EMBL:KDR83761.1, ECO:0000313|Proteomes:UP000027222};
RN [1] {ECO:0000313|Proteomes:UP000027222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 339.88 {ECO:0000313|Proteomes:UP000027222};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
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DR EMBL; KL142368; KDR83761.1; -; Genomic_DNA.
DR STRING; 685588.A0A067TKS0; -.
DR HOGENOM; CLU_000972_1_0_1; -.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000027222; Unassembled WGS sequence.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd21206; CH_IQGAP; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 13.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 9.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000027222}.
FT DOMAIN 467..575
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1189..1417
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1066..1100
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1669..1696
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1845 AA; 208993 MW; BCC39AE34D339122 CRC64;
MDRSNSVSST ASNGASNGSR SGSSAPFAYQ TRLLERTSSR SGGTSLSRSN SQSSIGILTN
TTGSSAGSVT PRRWTPSHRV GNSLDLVRGR WEERSRDALL EDTLNSTPSP TKEPSRVRSP
VTNVSGGTAS STDNHTIQDR DRPLTPTSFT STRDPYSTPK YLKRQTMPAP IIASPLSPNS
TGVSVEADSP TSSIPNRIHI PLQLSPTKSS SPWRTNTTET VPNLPSGPDS AAIVSSYTRL
HRANTLDSTS NNWMDSIGAR IGPMTPTSPL KSDSPKTSDS IFSNSRSTLG SETSVQSSST
HRRPLSRNSS TSSVDLSSPP TQSSPTSSVM HPAPYRSSYM SKKKAESYGE MLSLTGKRKL
GNHLPRIASG DGDDSWVGEP GPSKKSEDLT ERRLQRMRRL RNNEVNMDIQ KQTPTPSGIL
RGDGVAGLPG RVPLKAPNLA APTPSSRLLG GSWADKQRHL LQAYEYLCHV GEAQQWIEGC
LGEELEFGVV EMEDGLRNGV VLAKLVRAFQ GEGAVRRIYE APKLDFRHSD NINHFFTFVR
QVGLPEGFIF ELTDLYEKKN LPKVIYCIHA LSHLLARRGL AQRIGNLLGH LHFSDDQLKQ
TQKGLKEAGV AMPNFGNVGR ELAKEIDEEP EVEVETEDER RDRLLLENES SIIALQARAR
GYIARRTLMT FKDRMRLAER HISKFQTHSK GVLVRRGITA QRKSRDDLTP WAIALQARAR
AILAKRRRHA HLRSLKNSVR YIVKIQSQVR GVLQRRRFSR LKTALRKISV PTKHLQAVAR
GHILRRTQKE LTKYFFLPKI GLSVIALQAQ SRGVLVRHQI QQRMRGLHRT ERSIVSLQAH
CRGLILRRRL RSQLAKLENV THVVIAIQAA VRTYLARKRL LMLIRGLRKA TSVIIGVQAR
ARANLIRQQH VSIHKTLMDV KITKAVGRLQ ALAKASLIRN QHRELDKKLD IAVPDVIGVQ
AAGRGALLRR DYRAWRDHLR RNHHIATLLQ ALLRGAMQQL AFRKKMEYYR ANLNKVVKIQ
SLFRAKETRE QYRQLTLGKN VTVGTIKNFV HLLDDSEADF QEEIKVERLR KRVVEHIREN
QALENDINDL DTKIALVVQN LKSFEDFIKA RRRHGGDSAA LHAARVSLLA AHGDPFSGPN
TLDQDARRKL ELYQQLFYLL QTRGEYLSRL FIRLSMADKP ESTRRFTERV VLTLFGYGQD
RREDFLLLKL FQLAIREEID NASSIEDILT GYPMYLNISV HYVRPRQVTY VRDAFQGIIR
ELIDADDLDL EADPSAIHRA RVDVEEMRSG KPSLFAKDIP FRDAVTNPDT RAIYIRHLQV
LQWWTEAFLN VITQSTKKMP YSMRYLARET LLCLRAKFPG CPEEVYGACL GRLIFYRYIN
PALIAPEMFD IVPKTVNITT GKKNLAQISQ VLAQITSSLE FDDDKPSYVP INDFVRKAIQ
QLSTWFIEVA DVPDAEAQFH AHEFMDATVQ PKPIYISPNE IYTMHSLLLQ HQDFLESNND
DTMKVILAEL GGVPHLDNEE LKDARDTAIT LELTNRFAYV QDPHAEEKTL WVQAKRGVLA
ILRVQPAQDL LESLMRPVTE SDELLWEDIL EAEIENEIRQ MPRRQPSTMA TDSAYRLEDI
RSLKFAAVKA LAISNLLELE KQGKITREDG FQGILNAIAG DVRSKHRKRL QRQQEMESMN
EALRQLAERK KYFEEQIDSY NSYVETAMNT MQKGKGKKRS VLPFTKQYFH LRDLQRTGQA
PQFGSYLYSA KKLYDRGILL SIDQYSPRQF DKLQVTMSSN LAGVFNLTLD SSILGVASRI
AEEDIRMEDL LQAKYEKRPS LALFNGKVKV NFELFLFQIN KKFYA
//
