ID A0A067TRI6_GALM3 Unreviewed; 2131 AA.
AC A0A067TRI6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN ORFNames=GALMADRAFT_152431 {ECO:0000313|EMBL:KDR81578.1};
OS Galerina marginata (strain CBS 339.88).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Galerina.
OX NCBI_TaxID=685588 {ECO:0000313|EMBL:KDR81578.1, ECO:0000313|Proteomes:UP000027222};
RN [1] {ECO:0000313|Proteomes:UP000027222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 339.88 {ECO:0000313|Proteomes:UP000027222};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}.
CC -!- SIMILARITY: Belongs to the CLASP family.
CC {ECO:0000256|ARBA:ARBA00009549}.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR EMBL; KL142370; KDR81578.1; -; Genomic_DNA.
DR STRING; 685588.A0A067TRI6; -.
DR HOGENOM; CLU_000539_0_0_1; -.
DR OrthoDB; 5477703at2759; -.
DR Proteomes; UP000027222; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 3.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000027222};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..236
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 275..510
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 601..834
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 864..1098
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1226..1470
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1408..1442
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 508..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1093..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1903..1969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2073..2093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2110..2131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1515..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1927..1961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2131 AA; 228915 MW; 52C07CC11A52993B CRC64;
MDGPPPQEED FTSLPISERL AHKNWKARVS AYETLIKAFG NTASDNDPAF KPYINNVDLL
KKFATDANAV AQEKGVECLG ALVKFAGETA AKTREGIVPA LVDKCLGSTR IGTKNHAIDL
VTQYVEVENG GAGVVNDLLV GLSAKQPKAV AGCILALREV VQAFGVQVVP PPPILKILPK
IFSHSDKTVR AEGSNLTIVL YQYIGPGIEP WLADLKPVQV KELKDAFEAL EKDGKGHKSL
KPDRLTRAQA REAVSNEEVD VIPEEPEEVL LDPRAFAEAV DITPKLPASF QTNLKSSKWK
ERKEALDDLA TVLSNTPKIK DAPELSELSK SLAACIAKDA NINCVIVAAT CLEELAKGMM
VAFAKYRESV VALMLERLKE RKANVTDAIG SALDAVFATT TLSDTIPDLD GALKSKNPQV
KEGTLKFLSR CLASATSPIP PTQLKPLADT LAVLLEDGFE GARNEAANCF GTLMKMVGER
PLNATMETLP ELRKTKIKEA FEKATVKCKA GGPPAPRGPA GVPAKKAPPV AASKQTPKEE
EPAPKKVAAP PKPPVKAVPK KATATAPPAA AATKKVPSGA SAKPTTKPAT SPSSGNLDAV
KYKHSPEDAE ALAADLIPAS MMADLGDANW KTRLAALEEM SVWIEGEIQS LDAEVIVRAL
AKKGWNEKNF QVSAKLYANL AVLAQGCPSF GRSCAALCVV HLTDKLGDLK LKKPAGDTLM
AFAEKTSLQF VLGQAYEPLS KQKAPKVLAD AIAWVNSALI DFGISGVSLR ALIDFLKSAL
QNSNATVRTS ATKTLVTVKL FAGPSVKDLV EDLNPQLLNT ITSEFDKVDG QTPPEPCRTS
ADLANLAIES SQDSKAGAAD PLDDLFPRVE IDSLLKGTSI LADAKSDAWK TKKEALEALQ
GILDQGNNKR LKPSMGEIGQ TLKARVTDTN KAVQVLSLDI VSRIATGMGK PFEKHARLFV
LPICTVLADQ KANIRTAALQ ALTAIATGCE VEPMIPGLTT GIETTNPLQK STLLQWIVDW
FKDNTPSPSH DLRGWAPVIV SSLDDRSADV RKAAQALLPT LIHCSGFDFV MQQTNSLKPA
SRGSAVPLIQ AARPTASEPT QKAVATAKTS ISPPPASPRP ESPASAAFPD SKPSSKVSGV
RRKLPQGISR PDSRAESVDL GSKAIPGVAK KTIPATATSA KQAAPVPTNP ALPFSNMNSE
LKKTRLGKDA SRWINEGGPT RKDLAEALQN QMEPHTSKEL VSRLFSHDHN AVNDHITGLS
TIAEFYSGAL DADEHIEKLC LANLDLPLKY ISMKAHEPQS NLISKCLDVT EAILAFLRSV
NYQLTDNEAM CFVPTIIFKL GDAREQARAR VQQIIRTLPT VYPYSRVFQL LLDHGLKAKV
AKTRQGTLDE LSAILKKSGM GACEPSKAFP AVASLISDKD PQVRKSALGT LSEAYTLVGE
KVWALVGPLS AKDKTQLEER LRRVPGPSSQ GKADSITIPA PASGVARLTA TVPRPGSPSV
AVSRLARPAS PAQAFRSASP VQSTRPESPI RPAAANSNSH TSAIAVPPSS PGKTRPRSML
PSRLGRPRTN LVQPSAAPSI QESVPATPTS PPAVASRLDE PPARPRADSI VRSEVPDDIT
LTISSILSSD PTRSVEALKK IQKILSVGPD NGPSSPQYRE LAEHTEGLIE TITLQMAHVF
EHPKDLISDD NFRLAKHLIQ TLNNFCDHSF LAESLTVEIL TALLEELTLR LLETDDSPVK
KVKDLSRFIN MIILRLFATG RRMSIFRALF ALLLQIVKPF PSNGVLPDSK ESKVAELVLK
CVWKLARNIP QDLSETHLDP VELFPAIEHF LQSIPPNEWR ARATNKVPCG DMPLRTIKVI
IQHVVAHYGD DVYELLSASF DDPSATIVYP YVYRILNSSS RAATDAPVSR RNGAETFIPP
KSPGSSRPLS PQETASSVHS NHRPASHRTS PSSSSAHGHG QYSPNVEEPD PDAQLLVIIG
HISSETTGAL HKEGITELHH FLKAYPHKKP RVEKLLESTG AAFRKYINRA LASRAAEDQE
RNVAVADTLS KLEYNSQDTR NGSTATVTVV ANGSSEVASK TPTRASSVLE GTDQQEKLSR
LHDIFQYRSS TLSSGSSHGR STPSGLRTSL G
//
