ID A0A067TY77_GALM3 Unreviewed; 844 AA.
AC A0A067TY77;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=GALMADRAFT_151010 {ECO:0000313|EMBL:KDR83973.1};
OS Galerina marginata (strain CBS 339.88).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Galerina.
OX NCBI_TaxID=685588 {ECO:0000313|EMBL:KDR83973.1, ECO:0000313|Proteomes:UP000027222};
RN [1] {ECO:0000313|Proteomes:UP000027222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 339.88 {ECO:0000313|Proteomes:UP000027222};
RX PubMed=24958869; DOI=10.1073/pnas.1400592111;
RA Riley R., Salamov A.A., Brown D.W., Nagy L.G., Floudas D., Held B.W.,
RA Levasseur A., Lombard V., Morin E., Otillar R., Lindquist E.A., Sun H.,
RA LaButti K.M., Schmutz J., Jabbour D., Luo H., Baker S.E., Pisabarro A.G.,
RA Walton J.D., Blanchette R.A., Henrissat B., Martin F., Cullen D.,
RA Hibbett D.S., Grigoriev I.V.;
RT "Extensive sampling of basidiomycete genomes demonstrates inadequacy of the
RT white-rot/brown-rot paradigm for wood decay fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:9923-9928(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; KL142368; KDR83973.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A067TY77; -.
DR STRING; 685588.A0A067TY77; -.
DR HOGENOM; CLU_015501_0_0_1; -.
DR OrthoDB; 5491350at2759; -.
DR Proteomes; UP000027222; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR024604; GSG2_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR24419; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE; 1.
DR PANTHER; PTHR24419:SF18; SERINE_THREONINE-PROTEIN KINASE HASPIN; 1.
DR Pfam; PF12330; Haspin_kinase; 1.
DR SMART; SM01331; DUF3635; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000027222};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 699..784
FT /note="Serine/threonine-protein kinase haspin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01331"
FT REGION 209..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 94083 MW; CEED28EC3D2FBBC4 CRC64;
MLGSRTKQIN AYGKRGRRIV EATTDIKPSV SSTEIISIFD DLPPAPAMTS IANKMKKREN
VEPLKSKAPS VKVVGLQKKR RLSPVLSPAK KKQTSRVAQL IGDEVPKQNA CGPQTKPKPK
PLGLGNAEDP IVLSASPPRA PLSAIALNFT GSPTISHNLR HAREKTPLKS KKPFSPFVDV
DIIVLDDDGH TIRTEKRVSQ QKMIANPLNH RQRLEPPVKA KSALNTTPLD TDSEFEADNL
PKPPKHQAAR KQAIIISDDS DSEEECTPLK PKPTKASKDI LKRSFSFPKH PHAGSNMIVE
VLIPPAPYKL PRLPSTPETS AASSSPLLQD CDNLQESPIL PTQATEATPQ RYQFIPSPIL
KPRQLTPIRE GRRRFFEPPS PPSPTTPTDL DLSIDFSDLS LGLASQTQGL YQSDFVIHDY
LIPLLEECHQ ETSGPHNFST FIESFPYDQI LQSARERQGA DMQFRKIGEA SYSEVFGIGD
VVLKVIPLRD ETRLNGNPAE EEDGPAPSDA KDVRKEIIVT RAMGEVYDGY VKLLKTYVVK
GRYPEVLLRL WDEYNGRKGS ESVRPDTFKV SQVYAIIVLP NGGPDLEAYS FHNSSRTGWR
QACSIFWQVA KALAHAEHLV SFEHRDLHWG QILVKNLPTQ ANALKSLNLN RKAKPKTHRV
WMDDLSHGVQ ATVIDLGLSR MDAGDGENGD RVHWTPFDDE VFMGEGDYQF DVYRIMKELT
DGAWEGFYPI TNVVWLHYLL QKLLYSKGIK PPSTPRKTKV TPEVGLLMSC EGSFSEKDCY
ECLVDLESWL GRYITEMAPP TTKKKGKRKA QAPVKPVMYA GPARAGEVVA YGAKKGWIKA
TRLY
//
