ID A0A067XQ58_9CAUD Unreviewed; 302 AA.
AC A0A067XQ58;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
OS Caulobacter phage Cr30.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes.
OX NCBI_TaxID=1357714 {ECO:0000313|EMBL:AGS80934.1, ECO:0000313|Proteomes:UP000027481};
RN [1] {ECO:0000313|EMBL:AGS80934.1, ECO:0000313|Proteomes:UP000027481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ely B., Gibbs W.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KF301602; AGS80934.1; -; Genomic_DNA.
DR RefSeq; YP_009098807.1; NC_025422.1.
DR GeneID; 22276706; -.
DR KEGG; vg:22276706; -.
DR OrthoDB; 13491at10239; -.
DR Proteomes; UP000027481; Genome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AGS80934.1};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000027481};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AGS80934.1}.
FT DOMAIN 5..298
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 302 AA; 34947 MW; 62C08FA3D7B97E92 CRC64;
MEELQYLNLM YDLLYYGDYR MDRTGTGTYS KFGYQMRFNL ENDTLPLLTS KKVWFKGILH
ELLWMISGDT NIKYLQDNGV GIWNSWADEN GNLDRVYGAQ WRDWITPELL YQPCSQTDEK
WYTLEEFEAA GYRIDNQTSI CHKTIDQLAK VIEDIKTNPY SRRHIVTAWN PGEIDQMALP
PCHMTFQFGV TKGKLNCHLL QRSGDTALGI PYNIAFYSLL THMVAKITGL KAGEFVHTIV
DAHLYVNHVD GAKEQLSRTP LYPFPKIKIN GNQKTIDDFT FEDFELINYQ SHPKIDFGPA
AV
//
