ID A0A067XQQ4_9CAUD Unreviewed; 840 AA.
AC A0A067XQQ4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
OS Caulobacter phage Cr30.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes.
OX NCBI_TaxID=1357714 {ECO:0000313|EMBL:AGS81160.1, ECO:0000313|Proteomes:UP000027481};
RN [1] {ECO:0000313|EMBL:AGS81160.1, ECO:0000313|Proteomes:UP000027481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ely B., Gibbs W.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; KF301602; AGS81160.1; -; Genomic_DNA.
DR RefSeq; YP_009099033.1; NC_025422.1.
DR GeneID; 22276932; -.
DR KEGG; vg:22276932; -.
DR OrthoDB; 165at10239; -.
DR Proteomes; UP000027481; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1280.300; -; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 3.40.1820.10; DnaQ-like 3'-5' exonuclease; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:AGS81160.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000027481};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AGS81160.1};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 106..272
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 352..573
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 840 AA; 97878 MW; 3D4ADA1A5AEE8BC6 CRC64;
MAKYDLYTSV FQRGDIIYYR GYSETGQRVS ARIPYKPYLF IPSKKTSSEF KTLDGKPVDK
IEFDSIKEAK EFCKSYEDVD GFEISGNQAF LYPFLNDNHK EDIDYRKDRL KIGYYDLEVD
TENGFASVEN PWQPITLIGL RINERRMVFG WYDDYIPDEE DGNLEYIKCD NEHDMLLKFL
NVWEHEDIDV ISGWNIEGYD NTYLVNRLRM LFDEKTANRL SPWGMIDDGK DVDKYGKEII
TRTIKGIISA DYMRLYRKFT YSQQESYSLN HIAGIELDDY KISYSGSLGD LMRNDYKKFV
KYNAQDNDLV YRIDEKMNLL DQALTLSYMT RCTFEDVFGT VKMWDSVFHW KLMKKNIVIP
PMKYRSKSEQ FAGAYVADIA PGRYKYLASF DVKSLYPSLV IWANLSPETY RGKLPKFYTV
DQLLAGKLEE REWLEERNLC LAANMTLWDK EVQGIFAEIM DWALTDRDMF KDKMKKAKQE
NIRNPAKELQ YLIAKCNNMQ MALKIFANSG FGAAGTPYFR YFSIELAEAI TVTGQLTIRW
VSERINKLLN QKFKTKDYNY CVYNDTDSVY VTLEPIVNEI FKDKPNASEK DKIQFMDKVC
KQLIEPFLEK CFLELADYLN AYKKDKITMK REALADSGFW LGAKNYVLSV HDNEGVKYDE
PDIKMMGIAA VKTSTPAVCR EMMKESIRIM LQESQRTLIS HINDCKADFM KLPFENVAFP
RGVNGLKKYP LINGQVQKGT PIHVKGSLLY NKMLKDKKVD SKYFPITDGE KIKFSYLKTP
NPLHEAVIAS NGPLPPEFEL DEYIDYETQF EKSFVEPIRS MAEAIGWSVE EKADLSSLFD
//
