ID A0A068NKG9_9ACTO Unreviewed; 664 AA.
AC A0A068NKG9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=FB03_08610 {ECO:0000313|EMBL:AIE83280.1};
OS Actinotignum schaalii.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinotignum.
OX NCBI_TaxID=59505 {ECO:0000313|EMBL:AIE83280.1, ECO:0000313|Proteomes:UP000035032};
RN [1] {ECO:0000313|EMBL:AIE83280.1, ECO:0000313|Proteomes:UP000035032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 27420 {ECO:0000313|EMBL:AIE83280.1,
RC ECO:0000313|Proteomes:UP000035032};
RX PubMed=25189588;
RA Kristiansen R., Dueholm M.S., Bank S., Nielsen P.H., Karst S.M.,
RA Cattoir V., Lienhard R., Grisold A.J., Olsen A.B., Reinhard M., Soby K.M.,
RA Christensen J.J., Prag J., Thomsen T.R.;
RT "Complete Genome Sequence of Actinobaculum schaalii Strain CCUG 27420.";
RL Genome Announc. 2:e00880-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP008802; AIE83280.1; -; Genomic_DNA.
DR RefSeq; WP_026429132.1; NZ_CP008802.1.
DR AlphaFoldDB; A0A068NKG9; -.
DR GeneID; 81702436; -.
DR KEGG; asg:FB03_08610; -.
DR Proteomes; UP000035032; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF45; ATP-DEPENDENT DNA HELICASE UVRD2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 9..291
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 292..536
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT DOMAIN 591..664
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 664 AA; 72434 MW; 842A068D82ECDF9A CRC64;
MDSPEELLEF LDPDQRAVAT ALRGPVCVRA GAGTGKTRAI TYRIAYGVRS GAYVPQNVLA
VTFTSRAAGE LRSRLRDLGV GGVPALTFHA AALRQLSYFW GTAVGGTTPR ITESKFGLVS
QAAGQIGLPT DKVSIRDLTA EIEWAKVSMI SPDNYPEAAL AAGRGEVAGQ LSTDIARLAK
TYEEVKTERR VLDFDDVLLL LVGILLDRAD IARQIREQYR HFVVDEYQDV SPLQHRLLQL
WLGDRKDLCV VGDVSQTIYS FAGASSTYLA RFQQEYPRAR VIELTRDYRS TPQIVAAANT
VIADDVSEGA VQLVSQRRSG RPVTFQEYES DGAEAAGVVS AIRALAAEGT ALSEIAILYR
TNAQSAEFEA ALSKAGVSYQ VRGAEKFFSR RDVREAMVAM RAAARSGVSG SLADNVRTVL
RQMGWRDEAP ATAGSAREKW EALHALITLA EDMEDSRDAS MMDFVVELEE RAATQNVPEL
EGVTLSSLHA AKGLEWEAVF LVGMSEGLMP ISLAKKPAAI EEERRLLYVG ITRAQEFLQI
SYAASSGHRS GKKVSRFLTG LWPQTDDEEA SRATRYRRRS RAAAEEFAAA YPEDVALFEE
LAAWRAERAQ ATGKPAYTIF HDTTLRALAI AKPRSIHALA QIKGVGATKL AIYGEEILAL
LAGH
//
