ID   A0A068R2I1_9GAMM        Unreviewed;       397 AA.
AC   A0A068R2I1;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Cystathionine beta-lyase {ECO:0000313|EMBL:CDG20315.1};
DE            EC=4.4.1.8 {ECO:0000313|EMBL:CDG20315.1};
GN   Name=metC {ECO:0000313|EMBL:CDG20315.1};
GN   ORFNames=XPG1_0660 {ECO:0000313|EMBL:CDG20315.1};
OS   Xenorhabdus poinarii G6.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=1354304 {ECO:0000313|EMBL:CDG20315.1, ECO:0000313|Proteomes:UP000032735};
RN   [1] {ECO:0000313|EMBL:CDG20315.1, ECO:0000313|Proteomes:UP000032735}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G6 {ECO:0000313|EMBL:CDG20315.1,
RC   ECO:0000313|Proteomes:UP000032735};
RA   Genoscope - CEA;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; FO704551; CDG20315.1; -; Genomic_DNA.
DR   RefSeq; WP_045957761.1; NZ_FO704551.1.
DR   AlphaFoldDB; A0A068R2I1; -.
DR   STRING; 1354304.XPG1_0660; -.
DR   KEGG; xpo:XPG1_0660; -.
DR   HOGENOM; CLU_018986_2_0_6; -.
DR   OrthoDB; 9805807at2; -.
DR   Proteomes; UP000032735; Chromosome.
DR   GO; GO:0004121; F:cystathionine beta-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:CDG20315.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2}.
FT   MOD_RES         206
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   397 AA;  43360 MW;  6A7A90F935AAC7C7 CRC64;
     MTKFDNTKFN KTKFDTQSVH AGYVPDHTGA VMPAIYATST YAQLAPGQHT GYEYSRSGNP
     TRDALERAIA ELENGTRGYA FGSGLAASST ILELLDKDSH IIAVDDLYGG TYRLLEKVRR
     RTAGLRVTYI EAGDTAALEA AIQPDTKMIW VETPTNPLLK LADLAAIAQI AQRHNIISVA
     DNTFASPYSQ RPLDLGFDIV VHSATKYLNG HSDVVAGLAV VGNNAELAEQ VAFLQNSIGG
     ILDPFSSFLV LRGIRTLALR MERHIANAEK IAHWLEQQPH VEKIYYPGLV SHPQHELAKR
     QMQGFGGMIS IVLKGDEDYT YRVIKALRLF TLAESLGGVE SLIGQPFNMT HASIPLERRL
     AAGIIPQLIR ISVGIENAED LIADLSQALE SASLPQK
//